About the Authors

Sarah A. Smith

Affiliation Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Debashish Ray

Affiliation Donnelly Centre, University of Toronto, Toronto, Canada

Kate B. Cook

Affiliation Department of Molecular Genetics, University of Toronto, Toronto, Canada

Michael J. Mallory

Affiliation Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Timothy R. Hughes

Affiliations Donnelly Centre, University of Toronto, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

Kristen W. Lynch

klync@mail.med.upenn.edu

Affiliation Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAS DR TRH KWL. Performed the experiments: SAS DR KBC MJM. Analyzed the data: SAS DR KBC MJM TRH KWL. Contributed reagents/materials/analysis tools: SAS DR KBC MJM TRH KWL. Wrote the manuscript: SAS DR TRH KWL.