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Research Article

Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint

  • James J. Burston equal contributor,

    equal contributor Contributed equally to this work with: James J. Burston, Devi Rani Sagar

    Affiliations: Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

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  • Devi Rani Sagar equal contributor,

    equal contributor Contributed equally to this work with: James J. Burston, Devi Rani Sagar

    Affiliations: Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

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  • Pin Shao,

    Affiliation: Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Mingfeng Bai,

    Affiliations: Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America

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  • Emma King,

    Affiliation: School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

    X
  • Louis Brailsford,

    Affiliation: School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

    X
  • Jenna M. Turner,

    Affiliation: School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

    X
  • Gareth J. Hathway,

    Affiliation: School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

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  • Andrew J. Bennett,

    Affiliation: School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

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  • David A. Walsh,

    Affiliation: Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom

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  • David A. Kendall,

    Affiliation: School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

    X
  • Aron Lichtman,

    Affiliation: Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, United States of America

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  • Victoria Chapman mail

    victoria.chapman@nottingham.ac.uk

    Affiliation: Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom

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  • Published: November 25, 2013
  • DOI: 10.1371/journal.pone.0080440

About the Authors

James J. Burston, Devi Rani Sagar, David A. Walsh, Victoria Chapman
Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom
James J. Burston, Devi Rani Sagar, Emma King, Louis Brailsford, Jenna M. Turner, Gareth J. Hathway, Andrew J. Bennett, David A. Kendall
School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
Pin Shao, Mingfeng Bai
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Mingfeng Bai
University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
Aron Lichtman
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, United States of America

Corresponding Author

Email: victoria.chapman@nottingham.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DRS JJB AJB DAK GJH DAW VC. Performed the experiments: DRS JJB LB JMT EK PS MB. Analyzed the data: DRS JJB LB JMT AB GJH VC. Contributed reagents/materials/analysis tools: PS MB AL. Wrote the paper: DRS JJB PS MB EK GJH AJB DAW DAK AL VC.