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Research Article

Long-Term Follow-Up of HPV16-Positive Women: Persistence of the Same Genetic Variant and Low Prevalence of Variant Co-Infections

  • Daan T. Geraets mail,

    daan.geraets@ddl.nl

    Affiliation: DDL Diagnostic Laboratory, Rijswijk, The Netherlands

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  • Leen-Jan van Doorn,

    Affiliation: DDL Diagnostic Laboratory, Rijswijk, The Netherlands

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  • Bernhard Kleter,

    Affiliation: DDL Diagnostic Laboratory, Rijswijk, The Netherlands

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  • Brigitte Colau,

    Affiliation: GlaxoSmithKline Vaccines, Rixensart, Belgium

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  • Diane M. Harper,

    Affiliation: Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, United States of America

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  • Wim G. V. Quint

    Affiliation: DDL Diagnostic Laboratory, Rijswijk, The Netherlands

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  • Published: November 11, 2013
  • DOI: 10.1371/journal.pone.0080382

About the Authors

Daan T. Geraets, Leen-Jan van Doorn, Bernhard Kleter, Wim G. V. Quint
DDL Diagnostic Laboratory, Rijswijk, The Netherlands
Brigitte Colau
GlaxoSmithKline Vaccines, Rixensart, Belgium
Diane M. Harper
Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, United States of America

Corresponding Author

Email: daan.geraets@ddl.nl

Competing Interests

The authors have read the journal's policy and have the following conflicts: All authors declared that the following interests are relevant to the submitted work. DG and BK have declared no conflicts of interest. LJvD and WQ are employees and shareholders of DDL Diagnostic Laboratory. BC is an employee of the GlaxoSmithKline group of companies and holds shares in GSK. The institutions at which DH has conducted HPV vaccine trials have received funding to support clinical trials on the vaccines discussed herein from Merck and Co and GlaxoSmithKline. DH has also received honoraria for speaking and for participation on advisory boards from Merck and Co. and GlaxoSmithKline. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DG LJvD BK BC DH WQ. Performed the experiments: DG LJvD BK. Analyzed the data: DG LJvD BC WQ. Contributed reagents/materials/analysis tools: BC DH WQ. Wrote the manuscript: DG LJvD BK BC DH WQ.