Advertisement
Research Article

DNA-PK Target Identification Reveals Novel Links between DNA Repair Signaling and Cytoskeletal Regulation

  • Ewa Kotula,

    Affiliations: Institut Curie, Centre National de Recherche Scientifique (CNRS) UMR3347, Institut National de la Santé et de Recherche Médicale (INSERM) U1021, Université Paris-Sud 11, Centre Universitaire, Orsay, France, DNA Therapeutics, Evry, France

    X
  • Wolfgang Faigle,

    Affiliations: Institut Curie, Centre de Recherche, Laboratory of Proteomic Mass Spectrometry, Paris, France, University Hospital Zürich, Department of Clinical Neuroimmunology and MS Research, Paris, France

    X
  • Nathalie Berthault,

    Affiliation: Institut Curie, Centre National de Recherche Scientifique (CNRS) UMR3347, Institut National de la Santé et de Recherche Médicale (INSERM) U1021, Université Paris-Sud 11, Centre Universitaire, Orsay, France

    X
  • Florent Dingli,

    Affiliation: Institut Curie, Centre de Recherche, Laboratory of Proteomic Mass Spectrometry, Paris, France

    X
  • Damarys Loew,

    Affiliation: Institut Curie, Centre de Recherche, Laboratory of Proteomic Mass Spectrometry, Paris, France

    X
  • Jian-Sheng Sun,

    Affiliations: DNA Therapeutics, Evry, France, Muséum National d’Histoire Naturelle, USM503, Paris, France

    X
  • Marie Dutreix mail,

    marie.dutreix@curie.fr

    Affiliation: Institut Curie, Centre National de Recherche Scientifique (CNRS) UMR3347, Institut National de la Santé et de Recherche Médicale (INSERM) U1021, Université Paris-Sud 11, Centre Universitaire, Orsay, France

    X
  • Maria Quanz

    Affiliations: Institut Curie, Centre National de Recherche Scientifique (CNRS) UMR3347, Institut National de la Santé et de Recherche Médicale (INSERM) U1021, Université Paris-Sud 11, Centre Universitaire, Orsay, France, DNA Therapeutics, Evry, France

    X
  • Published: November 25, 2013
  • DOI: 10.1371/journal.pone.0080313

About the Authors

Ewa Kotula, Nathalie Berthault, Marie Dutreix, Maria Quanz
Institut Curie, Centre National de Recherche Scientifique (CNRS) UMR3347, Institut National de la Santé et de Recherche Médicale (INSERM) U1021, Université Paris-Sud 11, Centre Universitaire, Orsay, France
Ewa Kotula, Jian-Sheng Sun, Maria Quanz
DNA Therapeutics, Evry, France
Wolfgang Faigle, Florent Dingli, Damarys Loew
Institut Curie, Centre de Recherche, Laboratory of Proteomic Mass Spectrometry, Paris, France
Wolfgang Faigle
University Hospital Zürich, Department of Clinical Neuroimmunology and MS Research, Paris, France
Jian-Sheng Sun
Muséum National d’Histoire Naturelle, USM503, Paris, France

Corresponding Author

Email: marie.dutreix@curie.fr

Competing Interests

E. Kotula is a recipient of a PhD fellowship cofinanced by DNA Therapeutics and M. Quanz is an employee of DNA Therapeutics. M. Dutreix and J-S. Sun are cofounders of DNA Therapeutics, the company holding the patent for the clinical use of Dbait32Hc. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MD JSS MQ. Performed the experiments: EK MQ NB WF FD. Analyzed the data: EK WF MD MQ. Contributed reagents/materials/analysis tools: DL JSS. Wrote the paper: EK MD MQ. Developed the mass spectrometry analysis: WF FD DL.