About the Authors

Alice H. Berger

Current address: Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America; Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Affiliation Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Ming Chen

Affiliation Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Alessandro Morotti

Affiliation Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Justyna A. Janas

Affiliation Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

Masaru Niki

Affiliation Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America

Roderick T. Bronson

Affiliation Rodent Histopathology Core, Dana-Farber/Harvard Cancer Center, Boston, Massachusetts, United States of America

Barry S. Taylor

Current address: Departments of Epidemiology and Biostatistics, Medicine, and the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

Affiliation Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Marc Ladanyi

Affiliations Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Linda Van Aelst

Affiliation Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

Katerina Politi

Current address: Department of Pathology and Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, United States of America

Affiliation Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Harold E. Varmus

Current address: National Cancer Institute, Bethesda, Maryland, United States of America

Affiliation Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Pier Paolo Pandolfi

ppandolf@bidmc.harvard.edu

Affiliation Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AHB MC AM LVA KP HEV PPP. Performed the experiments: AHB MC AM JAJ. Analyzed the data: AHB MC AM JAJ KP BST ML HEV PPP. Contributed reagents/materials/analysis tools: KP HEV MN. Wrote the manuscript: AHB PPP. Pathological review: RTB. Generated mouse models: MN KP AHB.