Combination of LC3 shRNA Plasmid Transfection and Genistein Treatment Inhibited Autophagy and Increased Apoptosis in Malignant Neuroblastoma in Cell Culture and Animal Models

Nishant Mohan; Mrinmay Chakrabarti; Naren L. Banik; Swapan K. Ray

doi:10.1371/journal.pone.0078958

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Open Access

Peer-reviewed

Research Article

Combination of LC3 shRNA Plasmid Transfection and Genistein Treatment Inhibited Autophagy and Increased Apoptosis in Malignant Neuroblastoma in Cell Culture and Animal Models

Nishant Mohan,

Affiliation Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States of America
⨯
Mrinmay Chakrabarti,

Affiliation Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States of America
⨯
Naren L. Banik,

Affiliation Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Swapan K. Ray

* E-mail: swapan.ray@uscmed.sc.edu

Affiliation Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States of America
⨯

Combination of LC3 shRNA Plasmid Transfection and Genistein Treatment Inhibited Autophagy and Increased Apoptosis in Malignant Neuroblastoma in Cell Culture and Animal Models

Nishant Mohan,
Mrinmay Chakrabarti,
Naren L. Banik,
Swapan K. Ray

Published: October 18, 2013
https://doi.org/10.1371/journal.pone.0078958

About the Authors

Nishant Mohan

Affiliation Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States of America

Mrinmay Chakrabarti

Affiliation Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States of America

Naren L. Banik

Affiliation Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, United States of America

Swapan K. Ray

* E-mail: swapan.ray@uscmed.sc.edu

Affiliation Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NM MC NLB SKR. Performed the experiments: NM MC. Analyzed the data: NM MC. Wrote the manuscript: NM MC NLB SKR.

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Autophagic cell death
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Cancer treatment
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Apoptosis
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Transfection
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Malignant tumors
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Neuroblastoma
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Neuroblastoma cells
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Mitochondria
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