HIV-1 Tat-Mediated Induction of CCL5 in Astrocytes Involves NF-κB, AP-1, C/EBPα and C/EBPγ Transcription Factors and JAK, PI3K/Akt and p38 MAPK Signaling Pathways

Anantha R. Nookala; Ankit Shah; Richard J. Noel; Anil Kumar

doi:10.1371/journal.pone.0078855

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Research Article

HIV-1 Tat-Mediated Induction of CCL5 in Astrocytes Involves NF-κB, AP-1, C/EBPα and C/EBPγ Transcription Factors and JAK, PI3K/Akt and p38 MAPK Signaling Pathways

Anantha R. Nookala,

Affiliation Division of Pharmacology and Toxicology, UMKC-School of Pharmacy, Kansas City, Missouri, United States of America
⨯
Ankit Shah,

Affiliation Division of Pharmacology and Toxicology, UMKC-School of Pharmacy, Kansas City, Missouri, United States of America
⨯
Richard J. Noel,

Affiliation Department of Biochemistry, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico, United States of America
⨯
Anil Kumar

* E-mail: kumaran@umkc.edu

Affiliation Division of Pharmacology and Toxicology, UMKC-School of Pharmacy, Kansas City, Missouri, United States of America
⨯

HIV-1 Tat-Mediated Induction of CCL5 in Astrocytes Involves NF-κB, AP-1, C/EBPα and C/EBPγ Transcription Factors and JAK, PI3K/Akt and p38 MAPK Signaling Pathways

Anantha R. Nookala,
Ankit Shah,
Richard J. Noel,
Anil Kumar

Published: November 11, 2013
https://doi.org/10.1371/journal.pone.0078855

About the Authors

Anantha R. Nookala

Affiliation Division of Pharmacology and Toxicology, UMKC-School of Pharmacy, Kansas City, Missouri, United States of America

Ankit Shah

Affiliation Division of Pharmacology and Toxicology, UMKC-School of Pharmacy, Kansas City, Missouri, United States of America

Richard J. Noel

Affiliation Department of Biochemistry, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico, United States of America

Anil Kumar

* E-mail: kumaran@umkc.edu

Affiliation Division of Pharmacology and Toxicology, UMKC-School of Pharmacy, Kansas City, Missouri, United States of America

Competing Interests

The authors have the following interests. Anil Kumar is a PLOS ONE Editorial Board member. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AK RN. Performed the experiments: AN AS. Analyzed the data: AN. Wrote the paper: AN AK.

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HIV-1
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Transcription factors
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Astrocytes
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Small interfering RNA
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Transfection
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Gene expression
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MAPK signaling cascades
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Cytokines
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