About the Authors

Alessandra Zanon

Contributed equally to this work with: Alessandra Zanon, Aleksandar Rakovic, Francisco S. Domingues, Irene Pichler

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany

Aleksandar Rakovic

Contributed equally to this work with: Alessandra Zanon, Aleksandar Rakovic, Francisco S. Domingues, Irene Pichler

Affiliation Institute of Neurogenetics, University of Lübeck, Lübeck, Germany

Hagen Blankenburg

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany

Nadezhda T. Doncheva

Affiliation Max Planck Institute for Informatics, Saarbrücken, Germany

Christine Schwienbacher

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany

Alice Serafin

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany

Adrian Alexa

Current address: Illumina, Cambridge Ltd, Cambridge, United Kingdom

Affiliation Max Planck Institute for Informatics, Saarbrücken, Germany

Christian X. Weichenberger

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany

Mario Albrecht

Affiliations Max Planck Institute for Informatics, Saarbrücken, Germany, Department of Bioinformatics, Institute of Biometrics and Medical Informatics, University Medicine Greifswald, Greifswald, Germany

Christine Klein

Affiliation Institute of Neurogenetics, University of Lübeck, Lübeck, Germany

Andrew A. Hicks

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany

Peter P. Pramstaller

Affiliations Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany, Department of Neurology, General Central Hospital, Bolzano, Italy, Department of Neurology, University of Lübeck, Lübeck, Germany

Francisco S. Domingues

Contributed equally to this work with: Alessandra Zanon, Aleksandar Rakovic, Francisco S. Domingues, Irene Pichler

irene.pichler@eurac.edu (IP); francisco.domingues@eurac.edu (FSD)

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany

Irene Pichler

Contributed equally to this work with: Alessandra Zanon, Aleksandar Rakovic, Francisco S. Domingues, Irene Pichler

irene.pichler@eurac.edu (IP); francisco.domingues@eurac.edu (FSD)

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany

Competing Interests

The authors have read the journal's policy and have the following conflicts: Peter P. Pramstaller received honoraria for serving on scientific boards and speaking from Novartis, Boehringer, GlaxoSmithKline, Lundbeck and UCB. Christine Klein is a member of the editorial board of “Neurology” and has served as editor of the “Continuum Issue Neurogenetics 2008” and as faculty at the Annual Meetings of the American Academy of Neurology since 2004. She is a consultant to Centogene and received honoraria for speaking from Boehringer Ingelheim and Orion Pharma. Dr. Klein is the recipient of a career development award from the Hermann and Lilly Schilling Foundation. She is funded by the Volkswagen Foundation, the Deutsche Forschungsgemeinschaft, the Possehl Foundation and received institutional support from the University of Luebeck for genetics research. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. Also, the current affiliation of Adrian Alexa, one of the co-authors of the paper, to Illumina, Cambridge Ltd, UK (stated on the first page of the manuscript) does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CK PPP AAH IP FSD. Performed the experiments: AZ AS IP AR CS. Analyzed the data: HB NTD CXW FSD. Contributed reagents/materials/analysis tools: AA MA. Wrote the paper: IP AZ FSD.