About the Authors

Melissa Vos

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Department of Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium

Blaise Lovisa

Contributed equally to this work with: Blaise Lovisa, Ann Geens

Affiliations Medos International Sàrl, Le Locle, Switzerland, Swiss Federal Institute of Technology (EPFL), Medical Photonics Group, Institute of Chemical Sciences and Engineering (ISIC), Lausanne, Switzerland

Ann Geens

Contributed equally to this work with: Blaise Lovisa, Ann Geens

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Department of Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium

Vanessa A. Morais

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Department of Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium

Georges Wagnières

Affiliation Swiss Federal Institute of Technology (EPFL), Medical Photonics Group, Institute of Chemical Sciences and Engineering (ISIC), Lausanne, Switzerland

Hubert van den Bergh

Affiliation Swiss Federal Institute of Technology (EPFL), Medical Photonics Group, Institute of Chemical Sciences and Engineering (ISIC), Lausanne, Switzerland

Alec Ginggen

Affiliation Corporate Office of Science & Technology, Johnson & Johnson Services, Inc., New Brunswick, New Jersey, United States of America

Bart De Strooper

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Department of Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium

Yanik Tardy

Affiliation Medos International Sàrl, Le Locle, Switzerland

Patrik Verstreken

Patrik.verstreken@med.kuleuven.be

Affiliations VIB Center for the Biology of Disease, Leuven, Belgium, KU Leuven, Department of Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium

Competing Interests

The authors have read the journal’s policy and have the following conflicts: Bart De Strooper’s lab and Patrik Verstreken’s lab receive research funding from Janssen Pharmaceutica, Beerse, Belgium. Bart De Strooper is a consultant for Janssen Pharmaceutica, Envivo, and Remynd, Leuven, Belgium. Blaise Lovisa, Alec Gingen and Yanik Tardy are employees of Johnson&Johnson. However, the authors declare that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials reported in this work.

Author Contributions

Conceived and designed the experiments: MV BL VAM YT PV A. Ginggen. Performed the experiments: MV A. Geens. Analyzed the data: MV MV BL VAL GW HvdB BDS YT PV. Wrote the paper: MV PV.