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Research Article

Proteomic Profiling Identifies Distinct Protein Patterns in Acute Myelogenous Leukemia CD34+CD38- Stem-Like Cells

  • Steven M. Kornblau mail,

    skornblau@mdanderson.org

    Affiliation: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Amina Qutub,

    Affiliation: Department of Bioengineering, Rice University, Houston, Texas, United States of America

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  • Hui Yao,

    Affiliation: Department of Bioinformatics and Computational Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Heather York,

    Affiliation: Department of Bioengineering, Rice University, Houston, Texas, United States of America

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  • Yi Hua Qiu,

    Affiliation: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • David Graber,

    Affiliation: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Farhad Ravandi,

    Affiliation: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Jorge Cortes,

    Affiliation: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Michael Andreeff,

    Affiliation: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Nianxiang Zhang,

    Affiliation: Department of Bioinformatics and Computational Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Kevin R. Coombes

    Affiliation: Department of Bioinformatics and Computational Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Published: October 24, 2013
  • DOI: 10.1371/journal.pone.0078453

About the Authors

Steven M. Kornblau, Yi Hua Qiu, David Graber, Farhad Ravandi, Jorge Cortes, Michael Andreeff
Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
Amina Qutub, Heather York
Department of Bioengineering, Rice University, Houston, Texas, United States of America
Hui Yao, Nianxiang Zhang, Kevin R. Coombes
Department of Bioinformatics and Computational Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

Corresponding Author

Email: skornblau@mdanderson.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SMK AQ. Performed the experiments: SMK YHQ DG H. York AQ. Analyzed the data: SMK H. Yao AQ NZ KC. Contributed reagents/materials/analysis tools: SMK. Wrote the manuscript: SMK AQ H. Yao FR MA KC. Contributed to clinical care of the patients and assisted with manuscript preparation: FR JC.