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Research Article

Plasma Metabolomics Reveal Alterations of Sphingo- and Glycerophospholipid Levels in Non-Diabetic Carriers of the Transcription Factor 7-Like 2 Polymorphism rs7903146

  • Cornelia Then equal contributor,

    equal contributor Contributed equally to this work with: Cornelia Then, Simone Wahl

    Affiliations: Medizinische Klinik und Poliklinik IV, Diabetes Zentrum - Campus Innenstadt, Klinikum der Universität München, Munich, Germany, Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universität München and Helmholtz Zentrum München, Munich, Germany

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  • Simone Wahl equal contributor,

    equal contributor Contributed equally to this work with: Cornelia Then, Simone Wahl

    Affiliation: Research Unit of Molecular Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany

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  • Anna Kirchhofer,

    Affiliation: Medizinische Klinik und Poliklinik IV, Diabetes Zentrum - Campus Innenstadt, Klinikum der Universität München, Munich, Germany

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  • Harald Grallert,

    Affiliations: Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universität München and Helmholtz Zentrum München, Munich, Germany, Research Unit of Molecular Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany

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  • Susanne Krug,

    Affiliations: Else-Kroener-Fresenius-Centre for Nutritional Medicine, ZIEL - Research Centre for Nutrition and Food Sciences, Technical University München, Freising-Weihenstephan, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technical University München and Helmholtz Zentrum München, Munich, Germany

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  • Gabi Kastenmüller,

    Affiliation: Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany

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  • Werner Römisch-Margl,

    Affiliation: Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany

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  • Melina Claussnitzer,

    Affiliations: Else-Kroener-Fresenius-Centre for Nutritional Medicine, ZIEL - Research Centre for Nutrition and Food Sciences, Technical University München, Freising-Weihenstephan, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technical University München and Helmholtz Zentrum München, Munich, Germany

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  • Thomas Illig,

    Affiliation: Hannover Unified Biobank, Hannover Medical School, Hannover, Germany

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  • Margit Heier,

    Affiliation: Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany

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  • Christa Meisinger,

    Affiliation: Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany

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  • Jerzy Adamski,

    Affiliation: Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany.

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  • Barbara Thorand,

    Affiliations: Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany, German Center for Diabetes Research (DZD), Neuherberg, Germany

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  • Cornelia Huth,

    Affiliations: Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany, German Center for Diabetes Research (DZD), Neuherberg, Germany

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  • Annette Peters,

    Affiliations: Research Unit of Molecular Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany

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  • Cornelia Prehn,

    Affiliation: Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany.

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  • Ina Heukamp,

    Affiliation: Medizinische Klinik und Poliklinik IV, Diabetes Zentrum - Campus Innenstadt, Klinikum der Universität München, Munich, Germany

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  • Helmut Laumen,

    Affiliations: Else-Kroener-Fresenius-Centre for Nutritional Medicine, ZIEL - Research Centre for Nutrition and Food Sciences, Technical University München, Freising-Weihenstephan, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technical University München and Helmholtz Zentrum München, Munich, Germany

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  • Andreas Lechner,

    Affiliations: Medizinische Klinik und Poliklinik IV, Diabetes Zentrum - Campus Innenstadt, Klinikum der Universität München, Munich, Germany, Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universität München and Helmholtz Zentrum München, Munich, Germany

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  • Hans Hauner,

    Affiliations: Else-Kroener-Fresenius-Centre for Nutritional Medicine, ZIEL - Research Centre for Nutrition and Food Sciences, Technical University München, Freising-Weihenstephan, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technical University München and Helmholtz Zentrum München, Munich, Germany

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  • Jochen Seissler mail

    jochen.seissler@med.uni-muenchen.de

    Affiliations: Medizinische Klinik und Poliklinik IV, Diabetes Zentrum - Campus Innenstadt, Klinikum der Universität München, Munich, Germany, Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universität München and Helmholtz Zentrum München, Munich, Germany

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  • Published: October 24, 2013
  • DOI: 10.1371/journal.pone.0078430

About the Authors

Cornelia Then, Anna Kirchhofer, Ina Heukamp, Andreas Lechner, Jochen Seissler
Medizinische Klinik und Poliklinik IV, Diabetes Zentrum - Campus Innenstadt, Klinikum der Universität München, Munich, Germany
Cornelia Then, Harald Grallert, Andreas Lechner, Jochen Seissler
Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universität München and Helmholtz Zentrum München, Munich, Germany
Simone Wahl, Harald Grallert, Annette Peters
Research Unit of Molecular Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany
Susanne Krug, Melina Claussnitzer, Helmut Laumen, Hans Hauner
Else-Kroener-Fresenius-Centre for Nutritional Medicine, ZIEL - Research Centre for Nutrition and Food Sciences, Technical University München, Freising-Weihenstephan, Germany
Susanne Krug, Melina Claussnitzer, Helmut Laumen, Hans Hauner
Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technical University München and Helmholtz Zentrum München, Munich, Germany
Gabi Kastenmüller, Werner Römisch-Margl
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany
Thomas Illig
Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
Margit Heier, Christa Meisinger, Barbara Thorand, Cornelia Huth, Annette Peters
Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Neuherberg, Germany
Barbara Thorand, Cornelia Huth
German Center for Diabetes Research (DZD), Neuherberg, Germany
Jerzy Adamski, Cornelia Prehn
Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany.

Corresponding Author

Email: jochen.seissler@med.uni-muenchen.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CT HG MC TI MH BT CH HL AL HH JS. Performed the experiments: CT SW AK HG SK GK WRM MC TI MH CM JA CP IH HL AL HH JS. Analyzed the data: CT SW AK HG SK GK WRM MC TI MH JA AP CP IH HL AL HH JS. Wrote the manuscript: CT SW AK HG SK GK MC TI MH BT CH AP CM IH HL AL HH JS.