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Research Article

Evidence for a Retroviral Insertion in TRPM1 as the Cause of Congenital Stationary Night Blindness and Leopard Complex Spotting in the Horse

  • Rebecca R. Bellone mail,

    rbellone@ut.edu

    Affiliation: Department of Biology, University of Tampa, Tampa, Florida, United States of America

    X
  • Heather Holl,

    Affiliation: Department of Animal Science, Cornell University, Ithaca, New York, United States of America

    X
  • Vijayasaradhi Setaluri,

    Affiliation: Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America

    X
  • Sulochana Devi,

    Affiliation: Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America

    X
  • Nityanand Maddodi,

    Affiliation: Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America

    X
  • Sheila Archer,

    Affiliation: Quill Lake, Saskatchewan, Canada

    X
  • Lynne Sandmeyer,

    Affiliation: Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    X
  • Arne Ludwig,

    Affiliation: Department of Evolutionary Genetics, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany

    X
  • Daniel Foerster,

    Affiliation: Department of Evolutionary Genetics, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany

    X
  • Melanie Pruvost,

    Affiliations: Department of Evolutionary Genetics, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany, Epigenomic and Palaeogenomic Group, Institut Jacques Monod, Paris, France

    X
  • Monika Reissmann,

    Affiliation: Department of Breeding Biology and Molecular Genetics, Humboldt University Berlin, Berlin, Germany

    X
  • Ralf Bortfeldt,

    Affiliation: Department of Breeding Biology and Molecular Genetics, Humboldt University Berlin, Berlin, Germany

    X
  • David L. Adelson,

    Affiliation: School of Molecular and Biomedical Science, the University of Adelaide, South Australia, Australia

    X
  • Sim Lin Lim,

    Affiliation: School of Molecular and Biomedical Science, the University of Adelaide, South Australia, Australia

    X
  • Janelle Nelson,

    Affiliation: Department of Biology, University of Tampa, Tampa, Florida, United States of America

    X
  • Bianca Haase,

    Affiliation: Faculty of Veterinary Science, University of Sydney, Sydney, New South Wales, Australia

    X
  • Martina Engensteiner,

    Affiliation: Institute of Genetics, University of Bern, Bern, Switzerland

    X
  • Tosso Leeb,

    Affiliation: Institute of Genetics, University of Bern, Bern, Switzerland

    X
  • George Forsyth,

    Affiliation: Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    X
  • Michael J. Mienaltowski,

    Affiliation: Department of Molecular Pharmacology & Physiology, College of Medicine, University of South Florida, Tampa, Florida, United States of America

    X
  • Padmanabhan Mahadevan,

    Affiliation: Department of Biology, University of Tampa, Tampa, Florida, United States of America

    X
  • Michael Hofreiter,

    Affiliation: Department of Biology, The University of York, York, United Kingdom

    X
  • Johanna L. A. Paijmans,

    Affiliation: Department of Biology, The University of York, York, United Kingdom

    X
  • Gloria Gonzalez-Fortes,

    Affiliation: Department of Biology, The University of York, York, United Kingdom

    X
  • Bruce Grahn,

    Affiliation: Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    X
  • Samantha A. Brooks

    Affiliation: Department of Animal Science, Cornell University, Ithaca, New York, United States of America

    X
  • Published: October 22, 2013
  • DOI: 10.1371/journal.pone.0078280

About the Authors

Rebecca R. Bellone, Janelle Nelson, Padmanabhan Mahadevan
Department of Biology, University of Tampa, Tampa, Florida, United States of America
Heather Holl, Samantha A. Brooks
Department of Animal Science, Cornell University, Ithaca, New York, United States of America
Vijayasaradhi Setaluri, Sulochana Devi, Nityanand Maddodi
Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America
Sheila Archer
Quill Lake, Saskatchewan, Canada
Lynne Sandmeyer, Bruce Grahn
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Arne Ludwig, Daniel Foerster, Melanie Pruvost
Department of Evolutionary Genetics, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany
Melanie Pruvost
Epigenomic and Palaeogenomic Group, Institut Jacques Monod, Paris, France
Monika Reissmann, Ralf Bortfeldt
Department of Breeding Biology and Molecular Genetics, Humboldt University Berlin, Berlin, Germany
David L. Adelson, Sim Lin Lim
School of Molecular and Biomedical Science, the University of Adelaide, South Australia, Australia
Bianca Haase
Faculty of Veterinary Science, University of Sydney, Sydney, New South Wales, Australia
Martina Engensteiner, Tosso Leeb
Institute of Genetics, University of Bern, Bern, Switzerland
George Forsyth
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Michael J. Mienaltowski
Department of Molecular Pharmacology & Physiology, College of Medicine, University of South Florida, Tampa, Florida, United States of America
Michael Hofreiter, Johanna L. A. Paijmans, Gloria Gonzalez-Fortes
Department of Biology, The University of York, York, United Kingdom

Corresponding Author

Email: rbellone@ut.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Prepared the manuscript with contribution and input from all authors: RRB. Conceived and designed the experiments: RRB SA GF SAB VS SD NM DLA SLL AL MP DF RB MH JP GG MR. Performed the experiments: RRB GF MJM VS SD NM LS BG SA BH ME TL JN DLA SLL AL MP DF RB MH JP GG MR PM. Analyzed the data: RRB SAB HH VS SD NM DLA SLL AL MP DF RB MH JP GG MR PM. Contributed reagents/materials/analysis tools: RRB SA GF MJM LS BG ME TL AL MR PM. Wrote the manuscript: RRB.