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Research Article

Cutaneous Collateral Axonal Sprouting Re-Innervates the Skin Component and Restores Sensation of Denervated Swine Osteomyocutaneous Alloflaps

  • Zuhaib Ibrahim,

    Affiliation: Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Gigi Ebenezer,

    Affiliation: Department of Neurology and Neurosciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Joani M. Christensen,

    Affiliation: Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Karim A. Sarhane,

    Affiliation: Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Peter Hauer,

    Affiliation: Department of Neurology and Neurosciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Damon S. Cooney,

    Affiliation: Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Justin M. Sacks,

    Affiliation: Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Stefan Schneeberger,

    Affiliations: Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Innsbruck Medical University, Innsbruck, Austria

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  • W. P. Andrew Lee,

    Affiliation: Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Michael Polydefkis equal contributor mail,

    equal contributor Contributed equally to this work with: Michael Polydefkis, Gerald Brandacher

    brandacher@jhmi.edu (GD); mpolyde@jhmi.edu (MP)

    Affiliation: Department of Neurology and Neurosciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Gerald Brandacher equal contributor mail

    equal contributor Contributed equally to this work with: Michael Polydefkis, Gerald Brandacher

    brandacher@jhmi.edu (GD); mpolyde@jhmi.edu (MP)

    Affiliation: Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Published: October 18, 2013
  • DOI: 10.1371/journal.pone.0077646

About the Authors

Zuhaib Ibrahim, Joani M. Christensen, Karim A. Sarhane, Damon S. Cooney, Justin M. Sacks, Stefan Schneeberger, W. P. Andrew Lee, Gerald Brandacher
Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Gigi Ebenezer, Peter Hauer, Michael Polydefkis
Department of Neurology and Neurosciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Stefan Schneeberger
Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Innsbruck Medical University, Innsbruck, Austria

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZI WPAL MP GB. Performed the experiments: SS DSC GJE KAS JC PH JMS. Analyzed the data: GJE MP ZI JMS. Contributed reagents/materials/analysis tools: PH GJE. Wrote the manuscript: ZI GB MP WPAL GJE.