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Research Article

The Suppressive Role and Aberrent Promoter Methylation of BTG3 in the Progression of Hepatocellular Carcinoma

  • Zhenbing Lv equal contributor,

    equal contributor Contributed equally to this work with: Zhenbing Lv, Huichun Zou, Kaiwen Peng

    Affiliations: Department of Pathology, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China, Department of General Surgery, Nanchong Central Hospital, Nanchong City, Sichuan Province, People’s Republic of China

    X
  • Huichun Zou equal contributor,

    equal contributor Contributed equally to this work with: Zhenbing Lv, Huichun Zou, Kaiwen Peng

    Affiliation: Graduate School, Southern Medical University, Guangzhou City, Guangdong Province, People’s Republic of China

    X
  • Kaiwen Peng equal contributor,

    equal contributor Contributed equally to this work with: Zhenbing Lv, Huichun Zou, Kaiwen Peng

    Affiliation: Graduate School, Southern Medical University, Guangzhou City, Guangdong Province, People’s Republic of China

    X
  • Jianmei Wang,

    Affiliations: Department of Pathology, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China

    X
  • Yi Ding,

    Affiliation: Department of Radiotherapy, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong, People’s Republic of China

    X
  • Yuling Li,

    Affiliations: Department of Pathology, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China

    X
  • Xiaoli Ren,

    Affiliations: Department of Pathology, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China

    X
  • Feifei Wang,

    Affiliations: Department of Pathology, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China

    X
  • Rui Chang,

    Affiliation: Second School of Clinical Medicine, Southern Medical University, Guangzhou City, Guangdong Province, People’s Republic of China

    X
  • Li Liang mail,

    dyq@fimmu.com (YD); redsnow007@hotmail.com (LL)

    Affiliations: Department of Pathology, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China

    X
  • Yanqing Ding mail

    dyq@fimmu.com (YD); redsnow007@hotmail.com (LL)

    Affiliations: Department of Pathology, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China

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  • Published: October 17, 2013
  • DOI: 10.1371/journal.pone.0077473

About the Authors

Zhenbing Lv, Jianmei Wang, Yuling Li, Xiaoli Ren, Feifei Wang, Li Liang, Yanqing Ding
Department of Pathology, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China
Jianmei Wang, Yuling Li, Xiaoli Ren, Feifei Wang, Li Liang, Yanqing Ding
Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China
Zhenbing Lv
Department of General Surgery, Nanchong Central Hospital, Nanchong City, Sichuan Province, People’s Republic of China
Huichun Zou, Kaiwen Peng
Graduate School, Southern Medical University, Guangzhou City, Guangdong Province, People’s Republic of China
Yi Ding
Department of Radiotherapy, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong, People’s Republic of China
Rui Chang
Second School of Clinical Medicine, Southern Medical University, Guangzhou City, Guangdong Province, People’s Republic of China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LL Yanquing Ding. Performed the experiments: ZBL HCZ KWP YLL XLR RC. Analyzed the data: JMW FFW. Contributed reagents/materials/analysis tools: Yi Ding. Wrote the manuscript: ZBL LL.