About the Authors

Sofia Sisay

Contributed equally to this work with: Sofia Sisay, Gareth Pryce

Affiliation Neuroimmunology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Gareth Pryce

Contributed equally to this work with: Sofia Sisay, Gareth Pryce

Affiliation Neuroimmunology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Samuel J. Jackson

Affiliation Neuroimmunology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Carolyn Tanner

Affiliation School of Medical Science, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom

Ruth A. Ross

Affiliations School of Medical Science, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom, Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada

Gregory J. Michael

Affiliation Neuroimmunology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

David L. Selwood

Affiliation Biological and Medical Chemistry, the Wolfson Institute for Biomedical Research, University College London, London, United Kingdom

Gavin Giovannoni

Affiliation Neuroimmunology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

David Baker

david.baker@qmul.ac.uk

Affiliation Neuroimmunology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Competing Interests

Some of authors are named inventors on a patent (Masahiro O, Selwood D, Visintin C, Baker D, Pryce G. Modulators of cannabinoid receptors. WO2004100893) related to (R)3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-hydroxy-1-methyl-ethyl) benzamide. Selwood D,Baker D and Giovannoni G are shareholders and consultants to Canbex Ltd, which is University Spin-out Company, aimed at exploiting the intellectual property within W02004100893. Pryce G is a shareholder from Canbex Ltd. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SS GP SJJ RAR GJM DLS GG DB. Performed the experiments: SS GP SJJ CT DLS DB. Analyzed the data: SS GP CT RAR DB. Contributed reagents/materials/analysis tools: SS GP RAR DLS DB. Wrote the manuscript: SS GP DB. Initial Concepts: DB GP SJJ DLS. Obtained funding: DB GG SJJ DLS. Screening mice: SS SJJ GJM GP DB. In vivo Experiments: SS GP DB. Immunoassays: SS DB. Vas Deferens Assays: CT RAR. Draft Initial Manuscript: SS GP DB. Final Manuscript: SS GP SJJ CT RAR GJM DLS GG DB.