About the Authors

Paul A. Tambyah

Contributed equally to this work with: Paul A. Tambyah, Sugunavathi Sepramaniam

Affiliation Department of Medicine, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore

Sugunavathi Sepramaniam

Contributed equally to this work with: Paul A. Tambyah, Sugunavathi Sepramaniam

Affiliation Department of Biochemistry, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore

Jaminah Mohamed Ali

Affiliation Department of Medicine, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore

Siaw Ching Chai

Affiliation Department of Biochemistry, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore

Priyadharshini Swaminathan

Affiliation Department of Biochemistry, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore

Arunmozhiarasi Armugam

Affiliation Department of Biochemistry, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore

Kandiah Jeyaseelan

bchjeya@nus.edu.sg

Affiliations Department of Biochemistry, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore, Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia

Competing Interests

PAT has received research support from Baxter, ADAMAS, Fabentech, GSK and Sanofi-Pasteur. He has also received honoraria from Astra-Zeneca, Novartis and Johnson and Johnson. However this does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. All the other authors report no potential conflict of interest.

Author Contributions

Conceived and designed the experiments: KJ SS AA. Performed the experiments: SS PS SCC. Analyzed the data: SS AA. Contributed reagents/materials/analysis tools: KJ PAT JMA. Wrote the manuscript: KJ SS PAT AA.