About the Authors

Ping-Yen Liu

Contributed equally to this work with: Ping-Yen Liu, Liang-Yu Lin

Affiliations Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan

Liang-Yu Lin

Contributed equally to this work with: Ping-Yen Liu, Liang-Yu Lin

Affiliation Division of Endocrinology and Metabolism, Internal Medicine, National Yang-Ming University and Taipei Veterans General Hospital, Taipei, Taiwan

Hung-Ju Lin

Affiliation Division of Cardiology, Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

Chien-Hsun Hsia

Affiliation Division of Cardiology, Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan

Yi-Ren Hung

Affiliation Division of Endocrinology and Metabolism, Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan

Hung-I Yeh

Affiliation Division of Cardiology, Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan

Tao-Cheng Wu

Affiliation Division of Cardiology, Internal Medicine, National Yang-Ming University and Taipei Veterans General Hospital, Taipei, Taiwan

Ju-Yi Chen

Affiliation Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan

Kuo-Liong Chien

jwchen@vghtpe.gov.tw (JWC); klchien@ntu.edu.tw (KLC)

Affiliation Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan

Jaw-Wen Chen

jwchen@vghtpe.gov.tw (JWC); klchien@ntu.edu.tw (KLC)

Affiliation Institute of Pharmacology, National Yang-Ming University School of Medicine and Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan

Competing Interests

During study period, the Kowa company from Japan funded the medicine for the clinical trial. The authors did not belong to any employment, consultancy, patents, products in development or marketed products, etc. This medicine support did not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: KLC JWC. Performed the experiments: PYL LYL HJL CHH YRH HIY TCW JYC KLC JWC. Analyzed the data: PYL LYL HJL CHH YRH HIY TCW JYC KLC JWC. Contributed reagents/materials/analysis tools: KLC JWC PYL LYL HJL. Wrote the manuscript: PYL LYL.