About the Authors

Zhijun Zhang

Current address: Neuroscience and Neuroengineering Research Center, Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

Affiliation Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Sandra Almeida

Affiliation Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Yubing Lu

Affiliation Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Agnes L. Nishimura

Affiliation Department of Clinical Neuroscience, Institute of Psychiatry, London, United Kingdom

Lingtao Peng

Affiliations Department of Biological Chemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Howard Hughes Medical Institute, Worcester, Massachusetts, United States of America

Danqiong Sun

Current address: System Biosciences, Mountain View, California, United States of America

Affiliation Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America

Bei Wu

Affiliation Center for Neurologic Diseases, Harvard Medical School, Boston, Massachusetts, United States of America

Anna M. Karydas

Affiliation Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Maria C. Tartaglia

Current address: Krembil Neuroscience Centre and Department of Neurology, University of Toronto, Canada

Affiliation Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Jamie C. Fong

Affiliation Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Bruce L. Miller

Affiliation Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Robert V. Farese Jr

Affiliations Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America, Departments of Medicine and Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

Melissa J. Moore

Affiliations Department of Biological Chemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Howard Hughes Medical Institute, Worcester, Massachusetts, United States of America

Christopher E. Shaw

Affiliation Department of Clinical Neuroscience, Institute of Psychiatry, London, United Kingdom

Fen-Biao Gao

fen-biao.gao@umassmed.edu

Affiliation Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FBG ZZ SA. Performed the experiments: ZZ SA YL ALN LP DS BW. Analyzed the data: FBG ZZ SA YL LP BW MJM. Contributed reagents/materials/analysis tools: AMK MCT JCF BLM. Wrote the paper: FBG ZZ SA YL ALN CES RVF.