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Research Article

Characterizing the Role of Brain Derived Neurotrophic Factor Genetic Variation in Alzheimer’s Disease Neurodegeneration

  • Robyn A. Honea mail,

    rhonea@kumc.edu

    Affiliation: Department of Neurology, University of Kansas Alzheimer’s Disease Center, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Carlos Cruchaga,

    Affiliation: Department of Psychiatry & Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Rodrigo D. Perea,

    Affiliation: Department of Neurology, University of Kansas Alzheimer’s Disease Center, University of Kansas Medical Center, Kansas City, Kansas, United States of America

    X
  • Andrew J. Saykin,

    Affiliations: Center for Neuroimaging, Division of Imaging Sciences, Department of Radiology, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

    X
  • Jeffrey M. Burns,

    Affiliation: Department of Neurology, University of Kansas Alzheimer’s Disease Center, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Daniel R. Weinberger,

    Affiliations: Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, United States of America, Departments of Psychiatry, Neurology, Neuroscience and the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

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  • Alison M. Goate,

    Affiliation: Department of Psychiatry & Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • For the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
  • Published: September 26, 2013
  • DOI: 10.1371/journal.pone.0076001

About the Authors

Robyn A. Honea, Rodrigo D. Perea, Jeffrey M. Burns
Department of Neurology, University of Kansas Alzheimer’s Disease Center, University of Kansas Medical Center, Kansas City, Kansas, United States of America
Carlos Cruchaga, Alison M. Goate
Department of Psychiatry & Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Andrew J. Saykin
Center for Neuroimaging, Division of Imaging Sciences, Department of Radiology, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
Andrew J. Saykin
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
Daniel R. Weinberger
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland, United States of America
Daniel R. Weinberger
Departments of Psychiatry, Neurology, Neuroscience and the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

Corresponding Author

Email: rhonea@kumc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RAH CC AMG. Performed the experiments: RAH CC RDP. Analyzed the data: RAH CC RDP. Contributed reagents/materials/analysis tools: JMB AMG. Wrote the manuscript: RAG CC AJS JMB DRW AMG.