About the Authors

Roger Kenneth Whealands Smith

Affiliation Department of Clinical Sciences and Services, the Royal Veterinary College, University of London, Hatfield, United Kingdom

Natalie Jayne Werling

Affiliation Department of Biotherapeutics, National Institute for Biological Standards and Control, South Mimms, United Kingdom

Stephanie Georgina Dakin

Affiliation Department of Clinical Sciences and Services, the Royal Veterinary College, University of London, Hatfield, United Kingdom

Rafiqul Alam

Affiliation Department of Clinical Sciences and Services, the Royal Veterinary College, University of London, Hatfield, United Kingdom

Allen E. Goodship

Affiliation Institute of Orthopaedics & Musculo-Skeletal Science, University College London, Stanmore, United Kingdom

Jayesh Dudhia

jdudhia@rvc.ac.uk

Affiliation Department of Clinical Sciences and Services, the Royal Veterinary College, University of London, Hatfield, United Kingdom

Competing Interests

The authors have the following interests. This study was partly funded by VetCell Bioscience Ltd. RKS was a director of VetCell Bioscience Ltd, UK from 2002 - 2010. There are no patents, products in development or marketed products to declare. This does not alter their adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: RKWS AEG JD. Performed the experiments: RKWS NJW SGD RA JD. Analyzed the data: RKWS NJW SGD JD. Contributed reagents/materials/analysis tools: RKWS AEG JD. Wrote the manuscript: RKWS NJW JD.