Sliding over the Blocks in Enzyme-Free RNA Copying – One-Pot Primer Extension in Ice

Philipp M. G. Löffler; Joost Groen; Mark Dörr; Pierre-Alain Monnard

doi:10.1371/journal.pone.0075617

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Open Access

Peer-reviewed

Research Article

Sliding over the Blocks in Enzyme-Free RNA Copying – One-Pot Primer Extension in Ice

Philipp M. G. Löffler,

Affiliation Department of Physics, Chemistry and Pharmaceutical Sciences, University of Southern Denmark, Odense, Denmark
⨯
Joost Groen,

Affiliations Department of Physics, Chemistry and Pharmaceutical Sciences, University of Southern Denmark, Odense, Denmark, Institute for Molecules and Materials, Radboud University Nijmegen, Nijmegen, Netherlands
⨯
Mark Dörr,

Affiliations Department of Physics, Chemistry and Pharmaceutical Sciences, University of Southern Denmark, Odense, Denmark, Department of Biotechnology & Enzyme Catalysis, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany
⨯
Pierre-Alain Monnard

* E-mail: monnard@sdu.dk

Affiliation Department of Physics, Chemistry and Pharmaceutical Sciences, University of Southern Denmark, Odense, Denmark
⨯

Sliding over the Blocks in Enzyme-Free RNA Copying – One-Pot Primer Extension in Ice

Philipp M. G. Löffler,
Joost Groen,
Mark Dörr,
Pierre-Alain Monnard

Published: September 18, 2013
https://doi.org/10.1371/journal.pone.0075617

About the Authors

Philipp M. G. Löffler

Affiliation Department of Physics, Chemistry and Pharmaceutical Sciences, University of Southern Denmark, Odense, Denmark

Joost Groen

Affiliations Department of Physics, Chemistry and Pharmaceutical Sciences, University of Southern Denmark, Odense, Denmark, Institute for Molecules and Materials, Radboud University Nijmegen, Nijmegen, Netherlands

Mark Dörr

Affiliations Department of Physics, Chemistry and Pharmaceutical Sciences, University of Southern Denmark, Odense, Denmark, Department of Biotechnology & Enzyme Catalysis, Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany

Pierre-Alain Monnard

* E-mail: monnard@sdu.dk

Affiliation Department of Physics, Chemistry and Pharmaceutical Sciences, University of Southern Denmark, Odense, Denmark

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PL JG MD PAM. Performed the experiments: PL JG MD. Analyzed the data: PL JG PAM. Contributed reagents/materials/analysis tools: PL JG MD PAM. Wrote the manuscript: PL JG PAM.

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Monomers
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Eutectics
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High performance liquid chromatography
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Primer extension
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Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
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Nucleotides
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Oligomers
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Sequence motif analysis
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