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Research Article

Live Attenuated Rev-Independent Nef¯SIV Enhances Acquisition of Heterologous SIVsmE660 in Acutely Vaccinated Rhesus Macaques

  • Siddappa N. Byrareddy mail,

    siddappa.n.byrareddy@emory.edu

    Affiliations: Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Department of Pathology & Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America

    X
  • Mila Ayash-Rashkovsky,

    Affiliations: Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Victor G. Kramer,

    Affiliation: Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Sandra J. Lee,

    Affiliation: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Mick Correll,

    Affiliations: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for Cancer Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Francis J. Novembre,

    Affiliations: Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America

    X
  • Francois Villinger,

    Affiliations: Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America

    X
  • Welkin E. Johnson,

    Affiliation: Biology Department, Boston College, Boston, Massachusetts, United States of America

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  • Agneta von Gegerfelt,

    Affiliation: Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, Frederick, Maryland, United States of America

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  • Barbara K. Felber,

    Affiliation: Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, Frederick, Maryland, United States of America

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  • Ruth M. Ruprecht

    Affiliations: Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Texas Biomedical Research Institute, San Antonio, Texas, United States of America

    X
  • Published: September 30, 2013
  • DOI: 10.1371/journal.pone.0075556

About the Authors

Siddappa N. Byrareddy, Mila Ayash-Rashkovsky, Victor G. Kramer, Ruth M. Ruprecht
Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Siddappa N. Byrareddy, Mila Ayash-Rashkovsky, Ruth M. Ruprecht
Harvard Medical School, Boston, Massachusetts, United States of America
Sandra J. Lee, Mick Correll
Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Mick Correll
Center for Cancer Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Francis J. Novembre, Francois Villinger
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America
Francis J. Novembre
Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, United States of America
Francois Villinger
Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America
Welkin E. Johnson
Biology Department, Boston College, Boston, Massachusetts, United States of America
Agneta von Gegerfelt, Barbara K. Felber
Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, Frederick, Maryland, United States of America

Corresponding Author

Email: siddappa.n.byrareddy@emory.edu

Competing Interests

Dr Welkin Johnson is a PLOS ONE Editorial Board member and his role does not alter the authors' adherence to all of the PLOS ONE policies.

Author Contributions

Conceived and designed the experiments: SNB MAR RMR. Performed the experiments: SNB MAR WEJ VGK. Analyzed the data: SNB MAR VGK MC SJL WEJ FV RMR. Contributed reagents/materials/analysis tools: AVG BKF. Wrote the manuscript: SNB FV RMR. Managed the primate experiments: FV FJN.