About the Authors

Anthony J. O’Donoghue

Contributed equally to this work with: Anthony J. O’Donoghue, Ye Jin

Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, California, United States of America

Ye Jin

Contributed equally to this work with: Anthony J. O’Donoghue, Ye Jin

Affiliation US Innovation Center, Bayer Healthcare Pharmaceuticals, San Francisco, California, United States of America

Giselle M. Knudsen

Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, California, United States of America

Natascha C. Perera

Affiliation Comprehensive Pneumology Center, Institute of Lung Biology and Disease (ILBD), Helmholtz Zentrum München, Member of the German Center for Lung Research, Munich, Germany

Dieter E. Jenne

Affiliations Comprehensive Pneumology Center, Institute of Lung Biology and Disease (ILBD), Helmholtz Zentrum München, Member of the German Center for Lung Research, Munich, Germany, Max-Planck-Institute of Neurobiology, Planegg-Martinsried, Germany

John E. Murphy

Affiliation US Innovation Center, Bayer Healthcare Pharmaceuticals, San Francisco, California, United States of America

Charles S. Craik

Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco (UCSF), San Francisco, California, United States of America

Terry W. Hermiston

Terry.Hermiston@bayer.com

Affiliation US Innovation Center, Bayer Healthcare Pharmaceuticals, San Francisco, California, United States of America

Competing Interests

Ye Jin, John E. Murphy and Terry W. Hermiston are employees for Bayer HealthCare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: TH YJ CSC JEM AJO. Performed the experiments: AJO YJ GMK. Analyzed the data: AJO YJ GMK. Contributed reagents/materials/analysis tools: NCP DEJ. Wrote the manuscript: AJO YJ.