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Research Article

Staphylococcus aureus Alpha Toxin Suppresses Effective Innate and Adaptive Immune Responses in a Murine Dermonecrosis Model

  • Christine Tkaczyk,

    Affiliation: Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, United States of America

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  • Melissa M. Hamilton,

    Affiliation: Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, United States of America

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  • Vivekananda Datta,

    Affiliation: Pathology Department, MedImmune, LLC, Gaithersburg, Maryland, United States of America

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  • Xiang Ping Yang,

    Affiliation: Department of Respiratory, Inflammatory and Autoimmune Diseases, MedImmune, LLC, Gaithersburg, Maryland, United States of America

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  • Jamese J. Hilliard,

    Affiliation: Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, United States of America

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  • Geoffrey L. Stephens,

    Affiliation: Department of Respiratory, Inflammatory and Autoimmune Diseases, MedImmune, LLC, Gaithersburg, Maryland, United States of America

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  • Agnieszka Sadowska,

    Affiliation: Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, United States of America

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  • Lei Hua,

    Affiliation: Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, United States of America

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  • Terrence O’Day,

    Affiliation: Biostatistics Department, MedImmune, LLC, Gaithersburg, Maryland, United States of America

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  • JoAnn Suzich,

    Affiliation: Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, United States of America

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  • Charles Kendall Stover,

    Affiliation: Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, United States of America

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  • Bret R. Sellman mail

    sellmanb@medimmune.com

    Affiliation: Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, United States of America

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  • Published: October 02, 2013
  • DOI: 10.1371/journal.pone.0075103

About the Authors

Christine Tkaczyk, Melissa M. Hamilton, Jamese J. Hilliard, Agnieszka Sadowska, Lei Hua, JoAnn Suzich, Charles Kendall Stover, Bret R. Sellman
Department of Infectious Disease, MedImmune, LLC, Gaithersburg, Maryland, United States of America
Vivekananda Datta
Pathology Department, MedImmune, LLC, Gaithersburg, Maryland, United States of America
Xiang Ping Yang, Geoffrey L. Stephens
Department of Respiratory, Inflammatory and Autoimmune Diseases, MedImmune, LLC, Gaithersburg, Maryland, United States of America
Terrence O’Day
Biostatistics Department, MedImmune, LLC, Gaithersburg, Maryland, United States of America

Corresponding Author

Email: sellmanb@medimmune.com

Competing Interests

All authors are employees of MedImmune, LLC, (a wholly owned subsidiary of AstraZeneca Pharmaceuticals) whose company funded this study. The monoclonal antibody described in this manuscript is included in a pending patent application. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CT MMH XPY GLS BRS. Performed the experiments: CT MMH VD XPY AS. Analyzed the data: CT MMH VD XPY AS TO BRS. Contributed reagents/materials/analysis tools: LH JJH. Wrote the paper: CT JS CKS BRS.