High Incidence of HPV-Associated Head and Neck Cancers in FA Deficient Mice Is Associated with E7’s Induction of DNA Damage through Its Inactivation of Pocket Proteins

Jung Wook Park; Myeong-Kyun Shin; Henry C. Pitot; Paul F. Lambert

doi:10.1371/journal.pone.0075056

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Open Access

Peer-reviewed

Research Article

High Incidence of HPV-Associated Head and Neck Cancers in FA Deficient Mice Is Associated with E7’s Induction of DNA Damage through Its Inactivation of Pocket Proteins

Jung Wook Park,

Affiliation McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Myeong-Kyun Shin,

Affiliation McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Henry C. Pitot,

Affiliation McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Paul F. Lambert

* E-mail: lambert@oncology.wisc.edu

Affiliation McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯

High Incidence of HPV-Associated Head and Neck Cancers in FA Deficient Mice Is Associated with E7’s Induction of DNA Damage through Its Inactivation of Pocket Proteins

Jung Wook Park,
Myeong-Kyun Shin,
Henry C. Pitot,
Paul F. Lambert

Published: September 23, 2013
https://doi.org/10.1371/journal.pone.0075056

About the Authors

Jung Wook Park

Affiliation McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Myeong-Kyun Shin

Affiliation McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Henry C. Pitot

Affiliation McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Paul F. Lambert

* E-mail: lambert@oncology.wisc.edu

Affiliation McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JWP MKS PFL. Performed the experiments: JWP MKS. Analyzed the data: JWP MKS HCP PFL. Wrote the manuscript: JWP PFL.

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DNA damage
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Head and neck cancers
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Genetically modified animals
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HPV-16
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Tongue
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Esophagus
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Mouse models
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Carcinogenesis
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