Repetitive Concussive Traumatic Brain Injury Interacts with Post-Injury Foot Shock Stress to Worsen Social and Depression-Like Behavior in Mice

Kristen C. Klemenhagen; Scott P. O’Brien; David L. Brody

doi:10.1371/journal.pone.0074510

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Peer-reviewed

Research Article

Repetitive Concussive Traumatic Brain Injury Interacts with Post-Injury Foot Shock Stress to Worsen Social and Depression-Like Behavior in Mice

Kristen C. Klemenhagen,

Affiliation Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Scott P. O’Brien,

Affiliation Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
David L. Brody

* E-mail: brodyd@neuro.wustl.edu

Affiliations Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Hope Center for Neurological Disorders, St. Louis, Missouri, United States of America
⨯

Repetitive Concussive Traumatic Brain Injury Interacts with Post-Injury Foot Shock Stress to Worsen Social and Depression-Like Behavior in Mice

Kristen C. Klemenhagen,
Scott P. O’Brien,
David L. Brody

Published: September 18, 2013
https://doi.org/10.1371/journal.pone.0074510

About the Authors

Kristen C. Klemenhagen

Affiliation Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Scott P. O’Brien

Affiliation Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America

David L. Brody

* E-mail: brodyd@neuro.wustl.edu

Affiliations Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Hope Center for Neurological Disorders, St. Louis, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KCK DLB. Performed the experiments: KCK SPO. Analyzed the data: KCK SPO DLB. Wrote the manuscript: KCK SPO DLB.

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Animal sociality
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Traumatic brain injury
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Fear conditioning
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Mice
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Psychological stress
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Animal behavior
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