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Research Article

Circulating Antibody and Memory B-Cell Responses to C. difficile Toxins A and B in Patients with C. difficile-Associated Diarrhoea, Inflammatory Bowel Disease and Cystic Fibrosis

  • Tanya M. Monaghan,

    Affiliation: Institute of Infection, Immunity and Inflammation, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

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  • Adrian Robins,

    Affiliation: Division of Immunology, University of Nottingham, Nottingham, United Kingdom

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  • Alan Knox,

    Affiliation: Division of Respiratory Medicine, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

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  • Herbert F. Sewell,

    Affiliation: Division of Immunology, University of Nottingham, Nottingham, United Kingdom

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  • Yashwant R. Mahida mail

    yash.mahida@nottingham.ac.uk

    Affiliation: Institute of Infection, Immunity and Inflammation, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

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  • Published: September 10, 2013
  • DOI: 10.1371/journal.pone.0074452

About the Authors

Tanya M. Monaghan, Yashwant R. Mahida
Institute of Infection, Immunity and Inflammation, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
Adrian Robins, Herbert F. Sewell
Division of Immunology, University of Nottingham, Nottingham, United Kingdom
Alan Knox
Division of Respiratory Medicine, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

Corresponding Author

Email: yash.mahida@nottingham.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YRM TMM HFS AR AK. Performed the experiments: TMM AR. Analyzed the data: TMM YRM AR. Contributed reagents/materials/analysis tools: AR HFS AK YRM. Wrote the manuscript: YRM HFS TMM AK.