About the Authors

Joachim Theilhaber

joachim.theilhaber@sanofi.com

Affiliation Translational and Experimental Medicine, Sanofi Cambridge Research Center, Cambridge, Massachusetts, United States of America

Sanjay N. Rakhade

Affiliation Department of Clinical Studies, Genzyme – a Sanofi Company, Cambridge, Massachusetts, United States of America

Judy Sudhalter

Affiliation Translational and Experimental Medicine, Sanofi Cambridge Research Center, Cambridge, Massachusetts, United States of America

Nayantara Kothari

Affiliation Translational and Experimental Medicine, Sanofi Cambridge Research Center, Cambridge, Massachusetts, United States of America

Peter Klein

Affiliation Department of Pharmacology, University of Virginia, Charlottesville, Virginia, United States of America

Jack Pollard

Affiliation Translational and Experimental Medicine, Sanofi Cambridge Research Center, Cambridge, Massachusetts, United States of America

Frances E. Jensen

Affiliation Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

Five of the authors (JT, SNR, JS, NK and JP) are currently employees of the commercial sponsor of this research, Sanofi S.A., but this affiliation does not alter their adherence to PLOS One policies on sharing data and materials regarding the work presented here. JT is an employee of Sanofi-Aventis S.A. SNR is currently an employee of Genzyme, a Sanofi Company. None of the other authors has any conflict of interest to disclose. The authors confirm that they have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

Author Contributions

Conceived and designed the experiments: FEJ SNR JT JP. Performed the experiments: SNR JS NK PK. Analyzed the data: JT SNR. Contributed reagents/materials/analysis tools: JT SR FEJ. Wrote the paper: JT SNR.