About the Authors

Hartmut M. Hanauske-Abel

hanaushm@njms.rutgers.edu (HMH); mathews@njms.rutgers.edu (MBM)

Affiliations Department of Biochemistry & Molecular Biology, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America, Department of Pediatrics, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America, Department of Obstetrics, Gynecology & Women’s Health, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America

Deepti Saxena

Current address: Section of Infectious Diseases and International Health, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

Affiliation Department of Pediatrics, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America

Paul E. Palumbo

Current address: Section of Infectious Diseases and International Health, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

Affiliation Department of Pediatrics, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America

Axel-Rainer Hanauske

Current address: Eli Lilly and Company, Indianapolis, Indiana, United States of America

Affiliation Oncology Center and Medical Clinic III, Asklepios Clinic St. George, Hamburg, Germany

Augusto D. Luchessi

Current address: Laboratory of Biotechnology, School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil

Affiliation Department of Biochemistry & Molecular Biology, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America

Tavane D. Cambiaghi

Current address: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil

Affiliation Department of Biochemistry & Molecular Biology, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America

Mainul Hoque

Affiliation Department of Biochemistry & Molecular Biology, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America

Michael Spino

Affiliations Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, ApoPharma Inc., Toronto, Ontario, Canada

Darlene D'Alliessi Gandolfi

Affiliation Department of Chemistry, Manhattanville College, Purchase, New York, United States of America

Debra S. Heller

Affiliation Department of Pathology & Laboratory Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America

Sukhwinder Singh

Affiliation Department of Pathology & Laboratory Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America

Myung Hee Park

Affiliation Oral and Pharyngeal Cancer Branch, National Institute for Dental and Craniofacial Research, Bethesda, Maryland, United States of America

Bernadette M. Cracchiolo

Affiliation Department of Obstetrics, Gynecology & Women’s Health, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America

Fernando Tricta

Affiliation ApoPharma Inc., Toronto, Ontario, Canada

John Connelly

Affiliation ApoPharma Inc., Toronto, Ontario, Canada

Anthony M. Popowicz

Affiliation Department of Information Technology, Rockefeller University, New York, New York, United States of America

Richard A. Cone

Affiliation Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, United States of America

Bart Holland

Affiliation Department of Preventive Medicine & Community Health, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America

Tsafi Pe’ery

Affiliations Department of Biochemistry & Molecular Biology, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America, Department of Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America

Michael B. Mathews

hanaushm@njms.rutgers.edu (HMH); mathews@njms.rutgers.edu (MBM)

Affiliation Department of Biochemistry & Molecular Biology, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America

Competing Interests

MS, FT & JC are employees of ApoPharma Inc. UMDNJ (now Rutgers, The State University of New Jersey), Cornell University and NIH have one patent ("Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells," United States patent 5,849,587) and four pending patent applications. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. There are no further patents, patent applications, products in development or marketed products to declare.

Author Contributions

Conceived the concept: HMHA. Designed the experiments: HMHA DS PEP ARH ADL TDC MH DDAG AMP RAC TP MBM. Performed the experiments: HMHA DS PEP ADL TDC MH DDAG DSH SS RAC. Analyzed the data: HMHA DS PEP ARH ADL TDC MH MS DDAG DSH SS MHP BMC FT JC AMP RAC BH TP MBM. Contributed reagents/materials/analysis tools: HMHA PEP DDAG AMP MBM. Wrote the manuscript: HMHA TP MBM.