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Research Article

Lack of Association of Variants Previously Associated with Anti-TNF Medication Response in Rheumatoid Arthritis Patients: Results from a Homogeneous Greek Population

  • Maria I. Zervou,

    Affiliation: Laboratory of Molecular Medicine and Human Genetics, Medical School of Crete, Heraklion, Crete, Greece

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  • Efsevia Myrthianou,

    Affiliation: Laboratory of Molecular Medicine and Human Genetics, Medical School of Crete, Heraklion, Crete, Greece

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  • Irene Flouri,

    Affiliation: Department of Rheumatology, Clinical Immunology and Allergy, Medical School of Crete, Heraklion, Greece

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  • Darren Plant,

    Affiliation: NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom

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  • Gregory Chlouverakis,

    Affiliation: Department of Social Medicine, University of Crete, Heraklion, Greece

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  • Francesc Castro-Giner,

    Affiliation: Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Panayiota Rapsomaniki,

    Affiliation: Department of Rheumatology, Clinical Immunology and Allergy, Medical School of Crete, Heraklion, Greece

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  • Anne Barton,

    Affiliations: NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom

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  • Dimitrios T. Boumpas,

    Affiliations: Medical School, National and Kapodistrian University of Athens, Athens, Greece, Biomedical Research Foundation of the Academy of Athens, Athens, Greece, Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology–Hellas, Heraklion, Greece

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  • Prodromos Sidiropoulos equal contributor,

    equal contributor Contributed equally to this work with: Prodromos Sidiropoulos, George N. Goulielmos

    Affiliation: Department of Rheumatology, Clinical Immunology and Allergy, Medical School of Crete, Heraklion, Greece

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  • George N. Goulielmos equal contributor mail

    equal contributor Contributed equally to this work with: Prodromos Sidiropoulos, George N. Goulielmos

    goulielmos@med.uoc.gr

    Affiliation: Laboratory of Molecular Medicine and Human Genetics, Medical School of Crete, Heraklion, Crete, Greece

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  • Published: September 10, 2013
  • DOI: 10.1371/journal.pone.0074375

About the Authors

Maria I. Zervou, Efsevia Myrthianou, George N. Goulielmos
Laboratory of Molecular Medicine and Human Genetics, Medical School of Crete, Heraklion, Crete, Greece
Irene Flouri, Panayiota Rapsomaniki, Prodromos Sidiropoulos
Department of Rheumatology, Clinical Immunology and Allergy, Medical School of Crete, Heraklion, Greece
Darren Plant, Anne Barton
NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom
Gregory Chlouverakis
Department of Social Medicine, University of Crete, Heraklion, Greece
Francesc Castro-Giner
Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Anne Barton
Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Dimitrios T. Boumpas
Medical School, National and Kapodistrian University of Athens, Athens, Greece
Dimitrios T. Boumpas
Biomedical Research Foundation of the Academy of Athens, Athens, Greece
Dimitrios T. Boumpas
Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology–Hellas, Heraklion, Greece

Corresponding Author

Email: goulielmos@med.uoc.gr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GNG DP AB IF. Performed the experiments: MIZ EM IF PS PR DP. Analyzed the data: GNG MIZ DP GC PS DTB FCG. Contributed reagents/materials/analysis tools: PS DTB GNG PR AB FCG. Wrote the manuscript: GNG DP MIZ AB GC DTB FCG.