About the Authors

Yejie Shi

Affiliations Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin, United States of America

Hui Yuan

Affiliation Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Dong Kim

Affiliation Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Vishal Chanana

Affiliation Waisman Center, University of Wisconsin, Madison, Wisconsin, United States of America

Akemichi Baba

Affiliation Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan

Toshio Matsuda

Affiliation Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan

Pelin Cengiz

Affiliation Waisman Center, University of Wisconsin, Madison, Wisconsin, United States of America

Peter Ferrazzano

Affiliation Waisman Center, University of Wisconsin, Madison, Wisconsin, United States of America

Dandan Sun

sund@upmc.edu

Affiliations Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin, United States of America

Competing Interests

The HOE 642 used in this study was a kind gift from Aventis Pharma (Frankfurt, Germany). This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DS. Performed the experiments: YS HY DK VC PC PF. Analyzed the data: YS HY. Contributed reagents/materials/analysis tools: AB TM. Wrote the manuscript: YS HY DS.