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Research Article

Bruton’s Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin

  • Elaine F. Kenny mail,

    kennyef@tcd.ie

    Affiliation: Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

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  • Susan R. Quinn,

    Affiliation: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

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  • Sarah L. Doyle,

    Affiliation: Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

    Current address: Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland

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  • Paul M. Vink,

    Affiliation: Janssen Infectious Diseases BVBA, Beerse, Belgium

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  • Hans van Eenennaam,

    Affiliation: BioNovion B.V., Oss, The Netherlands

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  • Luke A. J. O’Neill

    Affiliation: Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

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  • Published: August 14, 2013
  • DOI: 10.1371/journal.pone.0074103

About the Authors

Elaine F. Kenny, Sarah L. Doyle, Luke A. J. O’Neill
Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
Susan R. Quinn
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
Paul M. Vink
Janssen Infectious Diseases BVBA, Beerse, Belgium
Hans van Eenennaam
BioNovion B.V., Oss, The Netherlands

Corresponding Author

Email: kennyef@tcd.ie

Competing Interests

Paul M. Vink is an employee at Janssen Infectious Diseases BVBA. Hans van Eenennaam is an employee at BioNovion B.V. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EFK SLD LAON. Performed the experiments: EFK SRQ PMV. Analyzed the data: EFK LAON. Contributed reagents/materials/analysis tools: EFK SLD HvE. Wrote the manuscript: EFK LAON.