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Research Article

Mechanism of Porcine Liver Xanthine Oxidoreductase Mediated N-Oxide Reduction of Cyadox as Revealed by Docking and Mutagenesis Studies

  • Chigang Chen equal contributor,

    equal contributor Contributed equally to this work with: Chigang Chen, Guyue Cheng

    Affiliation: National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei, China

    X
  • Guyue Cheng equal contributor,

    equal contributor Contributed equally to this work with: Chigang Chen, Guyue Cheng

    Affiliation: National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei, China

    X
  • Haihong Hao,

    Affiliation: National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei, China

    X
  • Menghong Dai,

    Affiliation: National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei, China

    X
  • Xu Wang,

    Affiliation: National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei, China

    X
  • Lingli Huang,

    Affiliation: National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei, China

    X
  • Zhenli Liu,

    Affiliation: National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei, China

    X
  • Zonghui Yuan mail

    yuan5802@mail.hzau.edu.cn

    Affiliation: National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei, China

    X
  • Published: September 09, 2013
  • DOI: 10.1371/journal.pone.0073912

About the Authors

Chigang Chen, Guyue Cheng, Haihong Hao, Menghong Dai, Xu Wang, Lingli Huang, Zhenli Liu, Zonghui Yuan
National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods, Huazhong Agricultural University, Wuhan, Hubei, China

Corresponding Author

Email: yuan5802@mail.hzau.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CC GC ZY. Performed the experiments: CC GC. Analyzed the data: CC GC HH. Contributed reagents/materials/analysis tools: MD XW LH ZL ZY. Wrote the paper: CC GC.