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Research Article

Specific Inhibition of Tumor Cells by Oncogenic EGFR Specific Silencing by RNA interference

  • Masaki Takahashi,

    Affiliation: Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan

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  • Tomoko Chiyo,

    Affiliation: Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan

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  • Takashi Okada,

    Affiliation: Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan

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  • Hirohiko Hohjoh mail

    hohjohh@ncnp.go.jp

    Affiliation: Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan

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  • Published: August 08, 2013
  • DOI: 10.1371/journal.pone.0073214

About the Authors

Masaki Takahashi, Hirohiko Hohjoh
Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
Tomoko Chiyo, Takashi Okada
Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan

Corresponding Author

Email: hohjohh@ncnp.go.jp

Competing Interests

Drs. Hohjoh and Takahashi have a pending patent regarding siRNAs designed in this study. Title of Invention: AGENT FOR SUPPRESSING EXPRESSION OF DOMINANT MUTANT GENE No. of Invention: WO2012043633 A1. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HH MT. Performed the experiments: MT TC HH. Analyzed the data: MT HH. Contributed reagents/materials/analysis tools: HH TO. Wrote the manuscript: MT HH.