Advertisement
Research Article

Nef-Specific CD8+ T Cell Responses Contribute to HIV-1 Immune Control

  • Emily Adland mail,

    emily.adland@paediatrics.ox.ac.uk

    Affiliation: Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom

    X
  • Jonathan M. Carlson,

    Affiliation: Microsoft Research, eScience Group, Los Angeles, California, United States of America

    X
  • Paolo Paioni,

    Affiliation: Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom

    X
  • Henrik Kløverpris,

    Affiliations: Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom, Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, KwaZulu-Natal Research Institute for Tuberculosis & HIV, K-RITH, Nelson R Mandela School of Medicine, University of KwaZuluNatal, Durban, South Africa

    X
  • Roger Shapiro,

    Affiliations: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana

    X
  • Anthony Ogwu,

    Affiliation: Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana

    X
  • Lynn Riddell,

    Affiliation: Department of Genitourinary Medicine, Northamptonshire Healthcare NHS Trust,Northampton General Hospital, Northampton, United Kingdom

    X
  • Graz Luzzi,

    Affiliation: Department of Genitourinary Medicine, Wycombe Hospital, High Wycombe, Bucks, United Kingdom

    X
  • Fabian Chen,

    Affiliation: Department of Sexual Health, Royal Berkshire Hospital, Reading, United Kingdom

    X
  • Thambiah Balachandran,

    Affiliation: Department of Genitourinary Medicine, Luton and Dunstable Hospital, Luton, United Kingdom

    X
  • David Heckerman,

    Affiliation: Microsoft Research, eScience Group, Los Angeles, California, United States of America

    X
  • Anette Stryhn,

    Affiliation: Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

    X
  • Anne Edwards,

    Affiliation: Oxford Department of Genitourinary Medicine, the Churchill Hospital, Oxford, United Kingdom

    X
  • Thumbi Ndung’u,

    Affiliations: HIV Pathogenesis Programme, the Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa, Ragon Institute of Massachusetts General Hospital, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

    X
  • Bruce D. Walker,

    Affiliations: HIV Pathogenesis Programme, the Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa, Ragon Institute of Massachusetts General Hospital, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

    X
  • Søren Buus,

    Affiliation: Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

    X
  • Philip Goulder,

    Affiliations: Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom, HIV Pathogenesis Programme, the Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa, Ragon Institute of Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Philippa C. Matthews

    Affiliation: Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom

    X
  • Published: September 02, 2013
  • DOI: 10.1371/journal.pone.0073117

About the Authors

Emily Adland, Paolo Paioni, Henrik Kløverpris, Philip Goulder
Department of Paediatrics, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom
Jonathan M. Carlson, David Heckerman
Microsoft Research, eScience Group, Los Angeles, California, United States of America
Roger Shapiro
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
Roger Shapiro, Anthony Ogwu
Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana
Lynn Riddell
Department of Genitourinary Medicine, Northamptonshire Healthcare NHS Trust,Northampton General Hospital, Northampton, United Kingdom
Graz Luzzi
Department of Genitourinary Medicine, Wycombe Hospital, High Wycombe, Bucks, United Kingdom
Fabian Chen
Department of Sexual Health, Royal Berkshire Hospital, Reading, United Kingdom
Thambiah Balachandran
Department of Genitourinary Medicine, Luton and Dunstable Hospital, Luton, United Kingdom
Henrik Kløverpris, Anette Stryhn, Søren Buus
Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Anne Edwards
Oxford Department of Genitourinary Medicine, the Churchill Hospital, Oxford, United Kingdom
Thumbi Ndung’u, Bruce D. Walker, Philip Goulder
HIV Pathogenesis Programme, the Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa
Thumbi Ndung’u, Bruce D. Walker, Philip Goulder
Ragon Institute of Massachusetts General Hospital, Boston, Massachusetts, United States of America
Henrik Kløverpris
KwaZulu-Natal Research Institute for Tuberculosis & HIV, K-RITH, Nelson R Mandela School of Medicine, University of KwaZuluNatal, Durban, South Africa
Thumbi Ndung’u, Bruce D. Walker
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
Philippa C. Matthews
Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: emily.adland@paediatrics.ox.ac.uk

Competing Interests

JMC and DH are employees of Microsoft and own stock in the company. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EA PG PCM. Performed the experiments: EA PP AS SB PCM. Analyzed the data: EA JMC HK DH PG PCM. Contributed reagents/materials/analysis tools: JMC HK RS AO LR GL FC TB DH AE TN BDW. Wrote the manuscript: EA PG PCM.