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Research Article

CXCL1 Contributes to β-Amyloid-Induced Transendothelial Migration of Monocytes in Alzheimer’s Disease

  • Ke Zhang,

    Affiliation: Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China

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  • Li Tian,

    Affiliation: Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China

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  • Li Liu,

    Affiliation: Department of Neurology, the First Affiliated Hospital, China Medical University, Shenyang, China

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  • Yu Feng,

    Affiliation: Department of Neurology, the First Affiliated Hospital, China Medical University, Shenyang, China

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  • Yan-Bin Dong,

    Affiliation: Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China

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  • Bo Li,

    Affiliation: Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China

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  • De-Shu Shang,

    Affiliation: Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China

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  • Wen-Gang Fang,

    Affiliation: Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China

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  • Yun-Peng Cao,

    Affiliation: Department of Neurology, the First Affiliated Hospital, China Medical University, Shenyang, China

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  • Yu-Hua Chen mail

    yhchen@mail.cmu.edu.cn

    Affiliation: Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China

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  • Published: August 14, 2013
  • DOI: 10.1371/journal.pone.0072744

About the Authors

Ke Zhang, Li Tian, Yan-Bin Dong, Bo Li, De-Shu Shang, Wen-Gang Fang, Yu-Hua Chen
Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China
Li Liu, Yu Feng, Yun-Peng Cao
Department of Neurology, the First Affiliated Hospital, China Medical University, Shenyang, China

Corresponding Author

Email: yhchen@mail.cmu.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KZ Y-HC. Performed the experiments: KZ Y-BD W-GF. Analyzed the data: BL D-SS. Contributed reagents/materials/analysis tools: LT LL YF BL D-SS W-GF Y-PC. Wrote the manuscript: KZ Y-HC.