Clinical Relevance of Gain-Of-Function Mutations of p53 in High-Grade Serous Ovarian Carcinoma

Hyo Jeong Kang; Sung-Min Chun; Kyu-Rae Kim; Insuk Sohn; Chang Ohk Sung

doi:10.1371/journal.pone.0072609

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Open Access

Peer-reviewed

Research Article

Clinical Relevance of Gain-Of-Function Mutations of p53 in High-Grade Serous Ovarian Carcinoma

Hyo Jeong Kang ,

Contributed equally to this work with: Hyo Jeong Kang, Sung-Min Chun

Affiliation Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
⨯
Sung-Min Chun ,

Contributed equally to this work with: Hyo Jeong Kang, Sung-Min Chun

Affiliations Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, ASAN Center for Cancer Genome Discovery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
⨯
Kyu-Rae Kim,

Affiliation Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
⨯
Insuk Sohn,

Affiliation Samsung Cancer Research Institute, Seoul, Korea
⨯
Chang Ohk Sung

* E-mail: co.sung@amc.seoul.kr

Affiliation Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
⨯

Clinical Relevance of Gain-Of-Function Mutations of p53 in High-Grade Serous Ovarian Carcinoma

Hyo Jeong Kang,
Sung-Min Chun,
Kyu-Rae Kim,
Insuk Sohn,
Chang Ohk Sung

Published: August 13, 2013
https://doi.org/10.1371/journal.pone.0072609

About the Authors

Hyo Jeong Kang

Contributed equally to this work with: Hyo Jeong Kang, Sung-Min Chun

Affiliation Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Sung-Min Chun

Contributed equally to this work with: Hyo Jeong Kang, Sung-Min Chun

Affiliations Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, ASAN Center for Cancer Genome Discovery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Kyu-Rae Kim

Affiliation Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Insuk Sohn

Affiliation Samsung Cancer Research Institute, Seoul, Korea

Chang Ohk Sung

* E-mail: co.sung@amc.seoul.kr

Affiliation Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: COS SMC. Analyzed the data: COS SMC IS. Contributed reagents/materials/analysis tools: COS. Wrote the manuscript: HJK KRK COS.

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Nonsense mutation
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Protein expression
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Insertion mutation
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Substitution mutation
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Metastasis
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Missense mutation
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DNA methylation
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Volcanic hotspots
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