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Research Article

Phospholipase D Toxins of Brown Spider Venom Convert Lysophosphatidylcholine and Sphingomyelin to Cyclic Phosphates

  • Daniel M. Lajoie,

    Affiliation: Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States of America

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  • Pamela A. Zobel-Thropp,

    Affiliation: Department of Biology, Lewis and Clark College, Portland, Oregon, United States of America

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  • Vlad K. Kumirov,

    Affiliation: Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States of America

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  • Vahe Bandarian,

    Affiliation: Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States of America

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  • Greta J. Binford,

    Affiliation: Department of Biology, Lewis and Clark College, Portland, Oregon, United States of America

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  • Matthew H. J. Cordes mail

    cordes@email.arizona.edu

    Affiliation: Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States of America

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  • Published: August 29, 2013
  • DOI: 10.1371/journal.pone.0072372

About the Authors

Daniel M. Lajoie, Vlad K. Kumirov, Vahe Bandarian, Matthew H. J. Cordes
Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States of America
Pamela A. Zobel-Thropp, Greta J. Binford
Department of Biology, Lewis and Clark College, Portland, Oregon, United States of America

Corresponding Author

Email: cordes@email.arizona.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MC VB DML. Performed the experiments: DML VKK PAZ. Analyzed the data: DML VKK MC VBB. Contributed reagents/materials/analysis tools: PAZ GJB VB. Wrote the paper: DML MC VB GJB.