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Research Article

A Macaque Model of Mesial Temporal Lobe Epilepsy Induced by Unilateral Intrahippocampal Injection of Kainic Acid

  • Ning Chen,

    Affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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  • Chong Liu,

    Affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

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  • Na Yan,

    Affiliation: School of Public Health and Family Medicine, Capital Medical University, Beijing, China

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  • Wei Hu,

    Affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Jian-guo Zhang,

    Affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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  • Yan Ge,

    Affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

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  • Fan-gang Meng mail

    fgmeng@ccmu.edu.cn

    Affiliation: Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

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  • Published: August 26, 2013
  • DOI: 10.1371/journal.pone.0072336

About the Authors

Ning Chen, Jian-guo Zhang
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Chong Liu, Yan Ge, Fan-gang Meng
Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
Na Yan
School of Public Health and Family Medicine, Capital Medical University, Beijing, China
Wei Hu
Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

Corresponding Author

Email: fgmeng@ccmu.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FM NC. Performed the experiments: NC CL. Analyzed the data: NY YG CL WH. Contributed reagents/materials/analysis tools: NC JZ FM. Wrote the paper: NC WH.