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Research Article

Soluble Variants of Human Recombinant Glutaminyl Cyclase

  • Cristiana Castaldo,

    Affiliation: Pharmacology Department, Siena Biotech, Siena, Italy

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  • Silvia Ciambellotti,

    Affiliation: Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino, Florence, Italy

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  • Raquel de Pablo-Latorre,

    Affiliation: Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino, Florence, Italy

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  • Daniela Lalli,

    Affiliation: Department of Chemistry, University of Florence, Sesto Fiorentino, Florence, Italy

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  • Valentina Porcari,

    Affiliation: Pharmacology Department, Siena Biotech, Siena, Italy

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  • Paola Turano mail

    turano@cerm.unifi.it

    Affiliations: Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino, Florence, Italy, Department of Chemistry, University of Florence, Sesto Fiorentino, Florence, Italy

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  • Published: August 15, 2013
  • DOI: 10.1371/journal.pone.0071657

About the Authors

Cristiana Castaldo, Valentina Porcari
Pharmacology Department, Siena Biotech, Siena, Italy
Silvia Ciambellotti, Raquel de Pablo-Latorre, Paola Turano
Magnetic Resonance Center (CERM), University of Florence, Sesto Fiorentino, Florence, Italy
Daniela Lalli, Paola Turano
Department of Chemistry, University of Florence, Sesto Fiorentino, Florence, Italy

Corresponding Author

Email: turano@cerm.unifi.it

Competing Interests

The authors have read the journal’s policy and have the following potential conflicts: Cristiana Castaldo and Valentina Porcari are employees of the drug discovery Company Siena Biotech. Siena Biotech was not directly involved in the study design, analysis, or writing of the paper, nor in the decision to submit the manuscript for publication. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DL RDP-L PT. Performed the experiments: CC SC RDP-L VP. Analyzed the data: DL CC VP. Contributed reagents/materials/analysis tools: SC RDP-L. Wrote the paper: RDP-L DL PT.