Carboxypeptidase E/NFα1: A New Neurotrophic Factor against Oxidative Stress-Induced Apoptotic Cell Death Mediated by ERK and PI3-K/AKT Pathways

Yong Cheng; Niamh X. Cawley; Y. Peng Loh

doi:10.1371/journal.pone.0071578

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Peer-reviewed

Research Article

Carboxypeptidase E/NFα1: A New Neurotrophic Factor against Oxidative Stress-Induced Apoptotic Cell Death Mediated by ERK and PI3-K/AKT Pathways

Yong Cheng,

Affiliation Section on Cellular Neurobiology, Program on Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Niamh X. Cawley,

Affiliation Section on Cellular Neurobiology, Program on Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Y. Peng Loh

* E-mail: lohp@mail.nih.gov

Affiliation Section on Cellular Neurobiology, Program on Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Carboxypeptidase E/NFα1: A New Neurotrophic Factor against Oxidative Stress-Induced Apoptotic Cell Death Mediated by ERK and PI3-K/AKT Pathways

Yong Cheng,
Niamh X. Cawley,
Y. Peng Loh

Published: August 15, 2013
https://doi.org/10.1371/journal.pone.0071578

About the Authors

Yong Cheng

Affiliation Section on Cellular Neurobiology, Program on Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

Niamh X. Cawley

Y. Peng Loh

* E-mail: lohp@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YPL NXC YC. Performed the experiments: YC NXC. Analyzed the data: YC NXC YPL. Wrote the paper: YPL NXC.

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Neurons
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Hippocampus
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Neuronal death
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Neuroprotectives
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Apoptosis
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Neuronal tuning
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AKT signaling cascade
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Cytotoxicity
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