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Research Article

Network-Level Structural Abnormalities of Cerebral Cortex in Type 1 Diabetes Mellitus

  • In Kyoon Lyoo equal contributor mail,

    equal contributor Contributed equally to this work with: In Kyoon Lyoo, Sujung Yoon

    inkylyoo@ewha.ac.kr

    Affiliation: Ewha Brain Institute & College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha W. University, Seoul, South Korea

    X
  • Sujung Yoon equal contributor,

    equal contributor Contributed equally to this work with: In Kyoon Lyoo, Sujung Yoon

    Affiliation: Department of Psychiatry, Catholic University of Korea College of Medicine, Seoul, South Korea

    X
  • Perry F. Renshaw,

    Affiliation: The Brain Institute, The University of Utah, Salt Lake City, Utah, United States of America

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  • Jaeuk Hwang,

    Affiliation: Department of Psychiatry, Soonchunhyang University College of Medicine, Seoul, South Korea

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  • Sujin Bae,

    Affiliation: The Brain Institute, The University of Utah, Salt Lake City, Utah, United States of America

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  • Gail Musen,

    Affiliations: Research Division, Joslin Diabetes Center, Boston, Massachusetts, United States of America, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Jieun E. Kim,

    Affiliation: Department of Brain and Cognitive Sciences, Ewha W. University Graduate School, Seoul, South Korea

    X
  • Nicolas Bolo,

    Affiliation: Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Hyeonseok S. Jeong,

    Affiliation: Interdisciplinary Program in Brain Science, Seoul National University College of Natural Sciences, Seoul, South Korea

    X
  • Donald C. Simonson,

    Affiliation: Department of Internal Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America

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  • Sun Hea Lee,

    Affiliation: Ewha Brain Institute & College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha W. University, Seoul, South Korea

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  • Katie Weinger,

    Affiliations: Research Division, Joslin Diabetes Center, Boston, Massachusetts, United States of America, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jiyoung J. Jung,

    Affiliation: Interdisciplinary Program in Brain Science, Seoul National University College of Natural Sciences, Seoul, South Korea

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  • Christopher M. Ryan,

    Affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Yera Choi,

    Affiliation: Interdisciplinary Program in Brain Science, Seoul National University College of Natural Sciences, Seoul, South Korea

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  • Alan M. Jacobson

    Affiliations: Research Division, Joslin Diabetes Center, Boston, Massachusetts, United States of America, Department of Psychiatry, Winthrop University Hospital, Mineola, New York, United States of America

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  • Published: August 23, 2013
  • DOI: 10.1371/journal.pone.0071304

About the Authors

In Kyoon Lyoo, Sun Hea Lee
Ewha Brain Institute & College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha W. University, Seoul, South Korea
Sujung Yoon
Department of Psychiatry, Catholic University of Korea College of Medicine, Seoul, South Korea
Perry F. Renshaw, Sujin Bae
The Brain Institute, The University of Utah, Salt Lake City, Utah, United States of America
Jaeuk Hwang
Department of Psychiatry, Soonchunhyang University College of Medicine, Seoul, South Korea
Gail Musen, Katie Weinger, Alan M. Jacobson
Research Division, Joslin Diabetes Center, Boston, Massachusetts, United States of America
Gail Musen, Nicolas Bolo, Katie Weinger
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America
Jieun E. Kim
Department of Brain and Cognitive Sciences, Ewha W. University Graduate School, Seoul, South Korea
Hyeonseok S. Jeong, Jiyoung J. Jung, Yera Choi
Interdisciplinary Program in Brain Science, Seoul National University College of Natural Sciences, Seoul, South Korea
Donald C. Simonson
Department of Internal Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America
Christopher M. Ryan
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Alan M. Jacobson
Department of Psychiatry, Winthrop University Hospital, Mineola, New York, United States of America

Corresponding Author

Email: inkylyoo@ewha.ac.kr

Competing Interests

Dr. Lyoo has received research support from Lundbeck, AstraZeneca, GSK, and Boryung Pharmaceutical. Dr. Renshaw has been a consultant to Roche, Novartis, Kyowa Hakko, and Repligen, and he has received research support from GlaxoSmithKline and Roche. Other authors have no conflicts of interest in relation to the subject of this study. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: IKL PFR GM AMJ. Performed the experiments: IKL PFR GM NB KW AMJ. Analyzed the data: IKL SY PFR JH SB GM JEK HSJ SHL KW JJJ YC AMJ. Contributed reagents/materials/analysis tools: IKL PFR AMJ. Wrote the paper: IKL SY PFR JH SB GM JEK NB HSJ DCS SHL KW JJJ CMR YC AMJ. Supervised study: IKL PFR AMJ. Critically revised the manuscript: IKL SY PFR JH SB GM JEK NB HSJ DCS SHL KW JJJ CMR YC AMJ.