About the Authors

Xuefeng Ren

Affiliations Department of Social and Preventive Medicine, the State University of New York, Buffalo, New York, United States of America, Guangdong Medical Laboratory Animal Center, Foshan, Guangdong, China, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, United States of America, NIEHS Center for Ecogenetics and Environmental Health, and the Department of Environmental and Occupational Health, University of Washington, Seattle, Washington, United States of America

Jessica C. Graham

Affiliations Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey Piscataway, New Jersey, United States of America, Joint Graduate Program in Toxicology. Rutgers, The State University of New Jersey University and the University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, United States of America

Lichen Jing

Affiliation Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, United States of America

Andrei M. Mikheev

Affiliation Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, United States of America

Yuan Gao

Affiliation Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, United States of America

Jenny Pan Lew

Affiliation Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, United States of America

Hong Xie

Affiliation Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, United States of America

Andrea S. Kim

Affiliation Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, United States of America

Xiuling Shang

Affiliation Department of Social and Preventive Medicine, the State University of New York, Buffalo, New York, United States of America

Cynthia Friedman

Affiliation Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, United States of America

Graham Vail

Affiliation Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey Piscataway, New Jersey, United States of America

Ming Zhu Fang

Affiliations NIEHS Center for Environmental Exposures and Disease, University of Medicine and Dentistry of New Jersey and Rutgers University, Piscataway, New Jersey, United States of America, Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey and Rutgers University, Piscataway, New Jersey, United States of America

Yana Bromberg

Affiliation Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, New Jersey, United States of America

Helmut Zarbl

zarbl@eohsi.rutgers.edu

Affiliations Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey Piscataway, New Jersey, United States of America, Joint Graduate Program in Toxicology. Rutgers, The State University of New Jersey University and the University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, United States of America, NIEHS Center for Environmental Exposures and Disease, University of Medicine and Dentistry of New Jersey and Rutgers University, Piscataway, New Jersey, United States of America, Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey and Rutgers University, Piscataway, New Jersey, United States of America, Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington, United States of America, NIEHS Center for Ecogenetics and Environmental Health, and the Department of Environmental and Occupational Health, University of Washington, Seattle, Washington, United States of America

Competing Interests

The authors would also like to disclose that author Helmut Zarbl is the Founding President of Gene Assess, Inc. (www.geneassessinc.com), which is developing diagnostic and prognostic products based on the level of functional FRY protein expressed in cancers. Jessica C. Graham and Helmut Zarbl are co-authors of the patent (pending) licensed by GeneAssess, Inc. (patent application number PCT/US2011/063553). This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. None of the other authors have a conflict of interest to declare.

Author Contributions

Conceived and designed the experiments: XR JG LJ HZ. Performed the experiments: XR JG LJ AM YG JL HX ASK XS CF GV MF. Analyzed the data: XR JG LJ YB HZ. Wrote the paper: XR JG HZ.