About the Authors
- Jennifer S. Dickey
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Contributed equally to this work with: Jennifer S. Dickey, Yanira Gonzalez
Current address: Office of In Vitro Diagnostics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, United States of America
Affiliation Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
- Yanira Gonzalez
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Contributed equally to this work with: Jennifer S. Dickey, Yanira Gonzalez
Affiliation Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
- Baikuntha Aryal
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Affiliation Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
- Steven Mog
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Affiliation Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, United States of America
- Asako J. Nakamura
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Current address: Department of Biological Sciences, Ibaraki University, Ibaraki, Japan
Affiliation Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, United States of America
- Christophe E. Redon
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Affiliation Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, United States of America
- Ulrich Baxa
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Affiliation Electron Microscopy Laboratory, Advanced Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
- Elliot Rosen
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Affiliation Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
- Gang Cheng
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Affiliation Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
- Jacek Zielonka
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Affiliation Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
- Palak Parekh
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Affiliation Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, United States of America
- Karen P. Mason
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Affiliation Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
- Joy Joseph
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Affiliation Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
- Balaraman Kalyanaraman
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Affiliation Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
- William Bonner
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Affiliation Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, United States of America
- Eugene Herman
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Affiliation Division of Drug Safety Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America
- Emily Shacter
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Affiliation Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
- V. Ashutosh Rao
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* E-mail: ashutosh.rao@fda.hhs.gov
Affiliation Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
Competing Interests
Eisai Co., Ltd. donated the SST-2 cells used in this study. The authors have no patents, products in development, marketed products or competing interests to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the United States Food and Drug Administration and the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the United States Government.
Author Contributions
Conceived and designed the experiments: VAR ES EH WB BK JSD. Performed the experiments: JSD YG BA SM AN CR UB ER GC JZ PP KM JJ BK EH VAR. Analyzed the data: VAR ES EH WB BK JSD. Contributed reagents/materials/analysis tools: JJ BK. Wrote the paper: VAR JSD BA SM.