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Research Article

Effects of Sildenafil on the Gastrocnemius and Cardiac Muscles of Rats in a Model of Prolonged Moderate Exercise Training

  • Barbara Rinaldi mail,

    barbara.rinaldi@unina2.it

    Affiliations: Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Centre of Excellence for Cardiovascular Diseases, Second University of Naples, Naples, Italy, Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Second University of Naples, Naples, Italy

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  • Maria Donniacuo,

    Affiliation: Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Centre of Excellence for Cardiovascular Diseases, Second University of Naples, Naples, Italy

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  • Loredana Sodano,

    Affiliation: Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Centre of Excellence for Cardiovascular Diseases, Second University of Naples, Naples, Italy

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  • Giulia Gritti,

    Affiliation: Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Centre of Excellence for Cardiovascular Diseases, Second University of Naples, Naples, Italy

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  • Simona Signoriello,

    Affiliation: Department of Mental and Physical Health and Preventive Medicine, Medical Statistics, Second University of Naples, Naples, Italy

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  • Elisabetta Parretta,

    Affiliation: Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Second University of Naples, Naples, Italy

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  • Liberato Berrino,

    Affiliation: Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Centre of Excellence for Cardiovascular Diseases, Second University of Naples, Naples, Italy

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  • Konrad Urbanek,

    Affiliation: Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Centre of Excellence for Cardiovascular Diseases, Second University of Naples, Naples, Italy

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  • Annalisa Capuano,

    Affiliation: Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Second University of Naples, Naples, Italy

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  • Francesco Rossi

    Affiliations: Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Centre of Excellence for Cardiovascular Diseases, Second University of Naples, Naples, Italy, Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Second University of Naples, Naples, Italy

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  • Published: July 29, 2013
  • DOI: 10.1371/journal.pone.0069954

About the Authors

Barbara Rinaldi, Maria Donniacuo, Loredana Sodano, Giulia Gritti, Liberato Berrino, Konrad Urbanek, Francesco Rossi
Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Centre of Excellence for Cardiovascular Diseases, Second University of Naples, Naples, Italy
Barbara Rinaldi, Elisabetta Parretta, Annalisa Capuano, Francesco Rossi
Department of Experimental Medicine, Section of Pharmacology “L. Donatelli”, Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Second University of Naples, Naples, Italy
Simona Signoriello
Department of Mental and Physical Health and Preventive Medicine, Medical Statistics, Second University of Naples, Naples, Italy

Corresponding Author

Email: barbara.rinaldi@unina2.it

Competing Interests

The authors declare that Sildenafil citrate was a donation from a commercial source (Pfizer Inc., Groton, CT, USA). This was stated in Acknowledgements and does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BR FR. Performed the experiments: BR MD LS GG EP KU. Analyzed the data: BR MD LS GG SS KU LB AC FR. Contributed reagents/materials/analysis tools: EP LB AC FR. Wrote the paper: BR MD SS LB AC FR.