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Research Article

Identification and Quantification of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Cells by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry

  • Güldal Kirkali,

    Affiliation: Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland, United States of America

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  • Pawel Jaruga,

    Affiliation: Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland, United States of America

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  • Prasad T. Reddy,

    Affiliation: Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland, United States of America

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  • Alessandro Tona,

    Affiliation: Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, Maryland, United States of America

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  • Bryant C. Nelson,

    Affiliation: Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, Maryland, United States of America

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  • Mengxia Li,

    Affiliation: Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • David M. Wilson III,

    Affiliation: Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Miral Dizdaroglu mail

    miral@nist.gov

    Affiliation: Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland, United States of America

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  • Published: July 29, 2013
  • DOI: 10.1371/journal.pone.0069894

About the Authors

Güldal Kirkali, Pawel Jaruga, Prasad T. Reddy, Miral Dizdaroglu
Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland, United States of America
Alessandro Tona, Bryant C. Nelson
Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, Maryland, United States of America
Mengxia Li, David M. Wilson III
Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Corresponding Author

Email: miral@nist.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MD GK PJ DMW. Performed the experiments: MD GK PJ PTR AT BCN ML. Analyzed the data: MD GK PJ BCN DMW. Contributed reagents/materials/analysis tools: MD PJ BCN DMW AT. Wrote the paper: MD. Obtained permission for use of cell lines: AT.