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Research Article

Vaccination with Single Chain Antigen Receptors for Islet-Derived Peptides Presented on I-Ag7 Delays Diabetes in NOD Mice by Inducing Anergy in Self-Reactive T-Cells

  • Werner Gurr mail,

    werner.gurr@yale.edu

    Affiliation: Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America

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  • Margaret Shaw,

    Affiliation: Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America

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  • Raimund I. Herzog,

    Affiliation: Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America

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  • Yanxia Li,

    Affiliation: Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America

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  • Robert Sherwin

    Affiliation: Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America

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  • Published: July 24, 2013
  • DOI: 10.1371/journal.pone.0069464

About the Authors

Werner Gurr, Margaret Shaw, Raimund I. Herzog, Yanxia Li, Robert Sherwin
Department of Internal Medicine, Yale University, School of Medicine, New Haven, Connecticut, United States of America

Corresponding Author

Email: werner.gurr@yale.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WG. Performed the experiments: WG MS YL. Analyzed the data: WG MS YL RS. Contributed reagents/materials/analysis tools: RIH. Wrote the paper: WG MS RS.