About the Authors
- Annie Albin Lumen
-
Current address: National Center for Toxicological Research/Food and Drug Administration, Jefferson, Arkansas, United States of America
¶AAL and LL are joint first authors on this work.
Affiliations Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America, Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
- Libin Li
-
¶AAL and LL are joint first authors on this work.
Affiliation Absorption Systems LLC, Exton, Pennsylvania, United States of America
- Jiben Li
-
Affiliation Absorption Systems LLC, Exton, Pennsylvania, United States of America
- Zeba Ahmed
-
Affiliations Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America, Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
- Zhou Meng
-
Affiliations Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America, Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
- Albert Owen
-
Affiliation Absorption Systems LLC, Exton, Pennsylvania, United States of America
- Harma Ellens
-
* E-mail: Harma.M.Ellens@gsk.com (HE); ihidalgo@absorption.com (IH); bentzj@drexel.edu (JB)
Affiliation Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
- Ismael J. Hidalgo
-
* E-mail: Harma.M.Ellens@gsk.com (HE); ihidalgo@absorption.com (IH); bentzj@drexel.edu (JB)
Affiliation Absorption Systems LLC, Exton, Pennsylvania, United States of America
- Joe Bentz
-
* E-mail: Harma.M.Ellens@gsk.com (HE); ihidalgo@absorption.com (IH); bentzj@drexel.edu (JB)
Affiliation Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America
Competing Interests
The authors have declared the following interests: Reagents were provided by GSK and by Absorption Systems, who also supported the execution of the experiments. AAL, ZA, ZM and HE are employed by GlaxoSmithKline and LL, JL, AO, and IJH by Absorption Systems LLC. Amprenavir and GF120918 were from GlaxoSmithKline. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
Author Contributions
Conceived and designed the experiments: AAL HE AO IH JB. Performed the experiments: AAL JL LL ZA ZM. Analyzed the data: AAL HE JB. Contributed reagents/materials/analysis tools: JB. Wrote the paper: AAL LL AO HE IH JB.