About the Authors

Matthew R. Steensma

matt.steensma@vai.org

Affiliations Department of Surgery, Spectrum Health Medical Group/Michigan State University College of Human Medicine, Grand Rapids, Michigan, United States of America, Center for Skeletal Disease and Tumor Metastasis, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

Wakenda K. Tyler

Affiliation Department of Orthopaedics, School of Medicine and Dentistry, University of Rochester, Rochester, New York, United States of America

Allison G. Shaber

Affiliation Research Division, Hospital for Special Surgery, New York, New York, United States of America

Steven R. Goldring

Affiliation Research Division, Hospital for Special Surgery, New York, New York, United States of America

F. Patrick Ross

Affiliation Research Division, Hospital for Special Surgery, New York, New York, United States of America

Bart O. Williams

Affiliation Center for Skeletal Disease and Tumor Metastasis, Van Andel Research Institute, Grand Rapids, Michigan, United States of America

John H. Healey

Affiliation Orthopaedic Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

P. Edward Purdue

Affiliation Research Division, Hospital for Special Surgery, New York, New York, United States of America

Competing Interests

We have the following interests. The institution of some of the authors SRG, EP and FPR at the Hospital for Special Surgery, New York has received grants from Boehringer Ingelheim. SRG serves on the board of and owns stock in Telik Inc and is a paid consultant to Bone Therapeutics. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: MRS WKT SRG FPR JHH. Performed the experiments: MRS WKT SRG FPR JHH PEP AS. Analyzed the data: MRS SRG FPR JHH PEP BOW. Contributed reagents/materials/analysis tools: MRS SRG JHH PEP BOW. Wrote the manuscript: MRS WKT SRG FPR JHH PEP.