About the Authors
- N. Maritza Dowling
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* E-mail: nmdowlin@biostat.wisc.edu
Affiliations Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, United States of America
- Carey E. Gleason
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Affiliations Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, United States of America, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America, Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America
- JoAnn E. Manson
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Affiliation Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
- Howard N. Hodis
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Affiliation Atherosclerosis Research Unit, University of Southern California, Los Angeles, California, United States of America
- Virginia M. Miller
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Affiliation Departments of Physiology and Biomedical Engineering and Surgery, Mayo Clinic, Rochester, Minnesota, United States of America
- Eliot A. Brinton
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Affiliation Department of Cardiovascular Genetics, University of Utah, Salt Lake City, Utah, United States of America
- Genevieve Neal-Perry
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Affiliation Department of Obstetrics and Gynecology and Women’s Health and Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States of America
- M. Nanette Santoro
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Affiliation Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, Colorado, United States of America
- Marcelle Cedars
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Affiliation Department of Obstetrics and Gynecology, University of California at San Francisco, San Francisco, California, United States of America
- Rogerio Lobo
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Affiliation Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
- George R. Merriam
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Affiliation VA Puget Sound Health Care System and Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington, United States of America
- Whitney Wharton
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Affiliations Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America, Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America
- Frederick Naftolin
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Affiliation Department of Obstetrics and Gynecology, New York University, New York, New York, United States of America
- Hugh Taylor
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Affiliation Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, United States of America
- S. Mitchell Harman
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Affiliation Kronos Longevity Research Institute and Phoenix VA Medical Center, Phoenix, Arizona, United States of America
- Sanjay Asthana
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Affiliations Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, United States of America, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America, Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veteran’s Hospital, Madison, Wisconsin, United States of America
Competing Interests
Bayer HealthCare Pharmaceuticals, Inc. supplied the CLIMARA® estradiol and placebo patches and Abbott Laboratories (formerly Solvay Pharmaceuticals) provided the micronized progesterone (PROMETRIUM®) and placebo capsules. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: NMD VMM JEM HNH EAB GNP MNS MC RL GRM FN HT SMH SA. Performed the experiments: NMD VMM JEM HNH EAB GNP MNS MC RL GRM FN HT SMH. Analyzed the data: NMD. Contributed reagents/materials/analysis tools: NMD. Wrote the paper: NMD. Revised the article for intellectual content: CEG VMM JEM HNH EAB GNP MNS MC RL GRM FN HT SMH SA. Acquisition of cognitive data: CEG WW.